How much does Ryplazim (plasminogen) cost?

$38.90per mg

Typical negotiated rate. In Arkansas, October 2026.

Insurers have agreed to pay about $38.90 for each mg of this drug. The price depends on where it is billed: about $39.81 from a physician practice, and about $32.36 from a hospital or other facility.

Work out the cost of a dose

This drug is priced per mg. Enter the amount given to see what insurers have agreed to pay for it.

Amount givenmg

In a doctor's office or clinic: $39.81
At a hospital outpatient department: $32.36

The same drug, in the same amount, costs 19% less at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 4 insurance carriers under federal price transparency rules.

Prices by location type

Billed by	Who charges it	Typical	Range
Physician practiceA doctor's office, clinic or independent provider	A doctor's office, clinic or independent provider	$39.81	$39.81 to $40.74
FacilityA hospital or hospital-owned outpatient department	A hospital or hospital-owned outpatient department	$32.36	$32.36 to $32.36

How much rates vary

Facilitymedian $32 · 10th to 90th $32 to $41Professionalmedian $40 · 10th to 90th $39 to $41

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier	Facility/Professional	Modifier	Typical Low	Median	Typical High
Aetna Setting Facility Modifier None Typical Low $40.74 Median $40.74 Typical High $40.74	Facility	None	$40.74	$40.74	$40.74
Aetna Setting Professional Modifier None Typical Low $39.81 Median $40.74 Typical High $40.74	Professional	None	$39.81	$40.74	$40.74
BCBS Arkansas Setting Facility Modifier None Typical Low $32.36 Median $32.36 Typical High $32.36	Facility	None	$32.36	$32.36	$32.36
BCBS Arkansas Setting Professional Modifier None Typical Low $32.36 Median $32.36 Typical High $32.36	Professional	None	$32.36	$32.36	$32.36
Cigna Setting Facility Modifier None Typical Low $40.74 Median $54.95 Typical High $57.54	Facility	None	$40.74	$54.95	$57.54
Cigna Setting Professional Modifier None Typical Low $40.74 Median $40.74 Typical High $40.74	Professional	None	$40.74	$40.74	$40.74
United Setting Professional Modifier None Typical Low $39.81 Median $39.81 Typical High $45.71	Professional	None	$39.81	$39.81	$45.71

Where Arkansas sits

The same service costs 1.8 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Arkansas· 49th of 51

$38.90

AK $64.57NE $36.31

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.