How much does Tysabri (natalizumab) cost?

$7,045per dose

One 287 mg dose, at the doctor's office rate. In Delaware, October 2026.

Negotiated ratewhat insurers pay per mg of the drug: $24.55 / mg
Average doseacross Medicare claims, discarded units included: × 287 mg
One dosedrug only; giving it and the visit are billed separately: $7,045

Work out the cost of a dose

This drug is priced per mg. Enter the amount given to see what insurers have agreed to pay for it. Prefilled with the average administration in Medicare claims, discarded units included.

Amount givenmg

In a doctor's office or clinic: $7,045
At a hospital outpatient department: $18,530

The same drug, in the same amount, costs 163% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

Few insurers publish rates for this combination, so treat this figure as a rough guide.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 4 insurance carriers under federal price transparency rules.

Where the price changes

Given at	Per mg	Per 287 mg dose
Doctor's office or clinic	$24.55	$7,045
Hospital outpatient department	$64.57	$18,530

How much rates vary

Facilitymedian $65 · 10th to 90th $25 to $87Professionalmedian $25 · 10th to 90th $25 to $65

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier	Facility/Professional	Modifier	Typical Low	Median	Typical High
Aetna Setting Facility Modifier None Typical Low $24.55 Median $24.55 Typical High $64.57	Facility	None	$24.55	$24.55	$64.57
Aetna Setting Professional Modifier None Typical Low $24.55 Median $25.70 Typical High $64.57	Professional	None	$24.55	$25.70	$64.57
Cigna Setting Facility Modifier None Typical Low $85.11 Median $85.11 Typical High $85.11	Facility	None	$85.11	$85.11	$85.11
Cigna Setting Professional Modifier None Typical Low $24.55 Median $24.55 Typical High $102.33	Professional	None	$24.55	$24.55	$102.33
Highmark BCBS Setting Facility Modifier None Typical Low $87.10 Median $87.10 Typical High $87.10	Facility	None	$87.10	$87.10	$87.10
United Setting Professional Modifier None Typical Low $24.55 Median $24.55 Typical High $34.67	Professional	None	$24.55	$24.55	$34.67

Where Delaware sits

The same service costs 1.6 times more in Arizona than in Oklahoma. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Delaware· 21st of 51

$25.70

AZ $38.02OK $23.99

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.