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Depo-Estradiol Cypionate Injection

Massachusetts rates for HCPCS J1000

Injection, depo-estradiol cypionate, up to 5 mg

Rates data updated October 2026.

How much does Depo-Estradiol (estradiol cypionate) cost?

$53.70per dose

One 5 mg dose, at the doctor's office rate. In Massachusetts, October 2026.

Negotiated ratewhat insurers pay per 5 mg of the drug
$53.70 / 5 mg
Average doseacross Medicare claims, discarded units included
× 5 mg
One dosedrug only; giving it and the visit are billed separately
$53.70

Work out the cost of a dose

This drug is priced per 5 mg. Enter the amount given to see what insurers have agreed to pay for it. Prefilled with the average administration in Medicare claims, discarded units included.

mg
In a doctor's office or clinic
$53.70
At a hospital outpatient department
$69.18

The same drug, in the same amount, costs 29% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Where the price changes

Given atPer 5 mgPer 5 mg dose
Doctor's office or clinic$53.70$53.70
Hospital outpatient department$69.18$69.18

How much rates vary

Facilitymedian $69 · 10th to 90th $18 to $148Professionalmedian $54 · 10th to 90th $51 to $78
$5$10$20$50$100$200facility $69professional $54

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$17.78
Median
$17.78
Typical High
$53.70
Aetna
Setting
Professional
Modifier
None
Typical Low
$53.70
Median
$53.70
Typical High
$53.70
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$2.75
Median
$17.78
Typical High
$169.82
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$51.29
Median
$52.48
Typical High
$77.62
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$53.70
Median
$61.66
Typical High
$112.20
Cigna
Setting
Facility
Modifier
None
Typical Low
$69.18
Median
$112.20
Typical High
$234.42
Cigna
Setting
Professional
Modifier
None
Typical Low
$47.86
Median
$53.70
Typical High
$53.70
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$53.70
Median
$70.79
Typical High
$83.18
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$51.29
Median
$53.70
Typical High
$89.13
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$2.75
Median
$17.78
Typical High
$169.82
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$51.29
Median
$52.48
Typical High
$77.62
United
Setting
Professional
Modifier
None
Typical Low
$51.29
Median
$51.29
Typical High
$87.10
Well Sense
Setting
Facility
Modifier
None
Typical Low
$57.54
Median
$75.86
Typical High
$125.89
Well Sense
Setting
Professional
Modifier
None
Typical Low
$53.70
Median
$53.70
Typical High
$64.57
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$26.92
Median
$26.92
Typical High
$26.92
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$10.72
Median
$10.72
Typical High
$10.72
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$8.13
Median
$8.13
Typical High
$8.13
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$5.37
Median
$5.37
Typical High
$5.37

Where Massachusetts sits

The same service costs 3.0 times more in Arizona than in Oklahoma. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 30th of 51

$53.70

AZ $81.28OK $27.54

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.