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C1 Esterase Inhibitor (Cinryze) Injection

Massachusetts rates for HCPCS J0598

Injection, C1 esterase inhibitor (human), Cinryze, 10 units

Rates data updated July 2026.

How much does Cinryze (human c1-esterase inhibitor) cost?

$66.07per 10 units

Typical negotiated rate. In Massachusetts, July 2026.

Insurers have agreed to pay about $66.07 for each 10 units of this drug. The price depends on where it is billed: about $66.07 from a physician practice, and about $77.62 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

Work out the cost of a dose

This drug is priced per 10 units. Enter the amount given to see what insurers have agreed to pay for it.

units
In a doctor's office or clinic
$66.07
At a hospital outpatient department
$77.62

The same drug, in the same amount, costs 17% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$66.07$66.07 to $67.61
FacilityA hospital or hospital-owned outpatient department$77.62$66.07 to $107

How much rates vary

Facilitymedian $78 · 10th to 90th $66 to $178Professionalmedian $66 · 10th to 90th $66 to $105
$100$200$500$1K$2K$5Kfacility $78professional $66

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$66.07
Median
$91.20
Typical High
$177.83
Aetna
Setting
Professional
Modifier
Global
Typical Low
$66.07
Median
$66.07
Typical High
$67.61
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$60.26
Median
$74.13
Typical High
$218.78
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$64.57
Median
$66.07
Typical High
$81.28
BCBS
Setting
Facility
Modifier
Global
Typical Low
$66.07
Median
$66.07
Typical High
$128.82
Cigna
Setting
Facility
Modifier
Global
Typical Low
$85.11
Median
$138.04
Typical High
$281.84
Cigna
Setting
Professional
Modifier
Global
Typical Low
$66.07
Median
$66.07
Typical High
$79.43
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$66.07
Median
$95.50
Typical High
$6,918.31
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$66.07
Median
$66.07
Typical High
$109.65
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$60.26
Median
$74.13
Typical High
$218.78
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$64.57
Median
$66.07
Typical High
$81.28
United
Setting
Facility
Modifier
Global
Typical Low
$66.07
Median
$66.07
Typical High
$141.25
United
Setting
Professional
Modifier
Global
Typical Low
$64.57
Median
$66.07
Typical High
$69.18

Where Massachusetts sits

The same service costs 2.3 times more in Delaware than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 44th of 51

$66.07

DE $155AL $66.07

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.