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C1 Esterase Inhibitor (Berinert) Injection

Massachusetts rates for HCPCS J0597

Injection, C1 esterase inhibitor (human), Berinert, 10 units

Rates data updated July 2026.

How much does Berinert (human c1-esterase inhibitor) cost?

$75.86per 10 units

Typical negotiated rate. In Massachusetts, July 2026.

Insurers have agreed to pay about $75.86 for each 10 units of this drug. The price depends on where it is billed: about $75.86 from a physician practice, and about $89.13 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

Work out the cost of a dose

This drug is priced per 10 units. Enter the amount given to see what insurers have agreed to pay for it.

units
In a doctor's office or clinic
$75.86
At a hospital outpatient department
$89.13

The same drug, in the same amount, costs 17% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$75.86$75.86 to $79.43
FacilityA hospital or hospital-owned outpatient department$89.13$75.86 to $132

How much rates vary

Facilitymedian $89 · 10th to 90th $76 to $209Professionalmedian $76 · 10th to 90th $76 to $123
$100$200$500$1K$2K$5Kfacility $89professional $76

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$75.86
Median
$104.71
Typical High
$186.21
Aetna
Setting
Professional
Modifier
Global
Typical Low
$75.86
Median
$75.86
Typical High
$79.43
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$60.26
Median
$199.53
Typical High
$263.03
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$75.86
Median
$79.43
Typical High
$93.33
BCBS
Setting
Facility
Modifier
Global
Typical Low
$75.86
Median
$75.86
Typical High
$151.36
Cigna
Setting
Facility
Modifier
Global
Typical Low
$97.72
Median
$158.49
Typical High
$331.13
Cigna
Setting
Professional
Modifier
Global
Typical Low
$75.86
Median
$75.86
Typical High
$85.11
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$75.86
Median
$109.65
Typical High
$6,918.31
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$75.86
Median
$75.86
Typical High
$125.89
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$60.26
Median
$199.53
Typical High
$263.03
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$75.86
Median
$79.43
Typical High
$93.33
United
Setting
Facility
Modifier
Global
Typical Low
$75.86
Median
$75.86
Typical High
$162.18
United
Setting
Professional
Modifier
Global
Typical Low
$75.86
Median
$75.86
Typical High
$91.20

Where Massachusetts sits

The same service costs 2.8 times more in Delaware than in Oklahoma. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 50th of 51

$75.86

DE $162OK $57.54

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.