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Cerliponase Alfa Injection

Massachusetts rates for HCPCS J0567 · Brineura

Injection, cerliponase alfa, 1 mg

Rates data updated October 2026.

How much does Brineura (cerliponase alfa) cost?

$123per mg

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $123 for each mg of this drug. The price depends on where it is billed: about $123 from a physician practice, and about $162 from a hospital or other facility.

Work out the cost of a dose

This drug is priced per mg. Enter the amount given to see what insurers have agreed to pay for it.

mg
In a doctor's office or clinic
$123
At a hospital outpatient department
$162

The same drug, in the same amount, costs 32% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$123$120 to $123
FacilityA hospital or hospital-owned outpatient department$162$135 to $219

How much rates vary

Facilitymedian $162 · 10th to 90th $95 to $282Professionalmedian $123 · 10th to 90th $120 to $178
$100$200$500facility $162professional $123

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$123.03
Median
$123.03
Typical High
$123.03
Aetna
Setting
Professional
Modifier
None
Typical Low
$123.03
Median
$123.03
Typical High
$123.03
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$95.50
Median
$100.00
Typical High
$234.42
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$91.20
Median
$120.23
Typical High
$177.83
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$154.88
Typical High
$281.84
Cigna
Setting
Facility
Modifier
None
Typical Low
$158.49
Median
$257.04
Typical High
$524.81
Cigna
Setting
Professional
Modifier
None
Typical Low
$123.03
Median
$123.03
Typical High
$141.25
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$158.49
Typical High
$181.97
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$120.23
Median
$123.03
Typical High
$204.17
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$95.50
Median
$100.00
Typical High
$234.42
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$91.20
Median
$120.23
Typical High
$177.83
United
Setting
Facility
Modifier
None
Typical Low
$123.03
Median
$123.03
Typical High
$123.03
United
Setting
Professional
Modifier
None
Typical Low
$120.23
Median
$120.23
Typical High
$204.17
Well Sense
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$181.97
Typical High
$288.40
Well Sense
Setting
Professional
Modifier
None
Typical Low
$123.03
Median
$123.03
Typical High
$147.91
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$61.66
Median
$61.66
Typical High
$61.66
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$24.55
Median
$24.55
Typical High
$24.55
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$18.20
Median
$18.20
Typical High
$18.20
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$12.30
Median
$12.30
Typical High
$12.30

Where Massachusetts sits

The same service costs 1.7 times more in Arizona than in Hawaii. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 26th of 51

$123

AZ $195HI $112

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.