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Separating Selected Cells From A Tissue Sample

South Dakota rates for HCPCS 88381

A laboratory preparation step in which a very small, specific group of cells is separated out from a tissue sample viewed under a microscope. Isolating those cells means that a later test measures only the area of interest instead of the surrounding normal tissue, which makes the result more reliable. It produces material for further testing rather than a diagnosis of its own.

Rates data updated October 2026.

How much does Separating Selected Cells From A Tissue Sample cost?

$263

Typical negotiated rate. In South Dakota, October 2026.

Insurers have agreed to pay about $263 for this service. The price depends on where it is billed: about $263 from a physician practice, and about $229 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$263$219 to $380
FacilityA hospital or hospital-owned outpatient department$229$229 to $427

How much rates vary

Facilitymedian $229 · 10th to 90th $178 to $427Professionalmedian $263 · 10th to 90th $120 to $427
$100$200$500$1Kfacility $229professional $263

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$128.82
Median
$128.82
Typical High
$128.82
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$144.54
Median
$144.54
Typical High
$144.54
Cigna
Setting
Facility
Modifier
None
Typical Low
$426.58
Median
$426.58
Typical High
$426.58
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$263.03
Median
$263.03
Typical High
$426.58
Medica
Setting
Facility
Modifier
None
Typical Low
$177.83
Median
$229.09
Typical High
$239.88
Medica
Setting
Professional
Modifier
None (both parts)
Typical Low
$97.72
Median
$245.47
Typical High
$1,348.96
Midlands
Setting
Professional
Modifier
None
Typical Low
$263.03
Median
$263.03
Typical High
$263.03
Sanford Health Plan
Setting
Professional
Modifier
None
Typical Low
$186.21
Median
$323.59
Typical High
$380.19
Sanford Health Plan
Setting
Professional
Modifier
26 · Professional part
Typical Low
$33.11
Median
$41.69
Typical High
$70.79
Sanford Health Plan
Setting
Professional
Modifier
TC · Technical part
Typical Low
$138.04
Median
$275.42
Typical High
$331.13
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$109.65
Median
$120.23
Typical High
$245.47
Wellmark
Setting
Professional
Modifier
None (both parts)
Typical Low
$389.05
Median
$426.58
Typical High
$426.58

Where South Dakota sits

The same service costs 6.5 times more in North Dakota than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 15th of 51

$263

ND $363AL $56.23

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.