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In Situ Hybridization Analysis of Tissue

Pennsylvania rates for HCPCS 88373

A laboratory analysis in which a piece of tissue is treated with a labeled probe that sticks to one specific stretch of genetic material, and the amount present is then measured. It is performed on a sample already being examined by a pathologist and is reported in addition to that examination.

Rates data updated October 2026.

How much does In Situ Hybridization Analysis of Tissue cost?

$66.07

Typical negotiated rate. In Pennsylvania, October 2026.

Insurers have agreed to pay about $66.07 for this service. The price depends on where it is billed: about $66.07 from a physician practice, and about $66.07 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$66.07$57.54 to $97.72
FacilityA hospital or hospital-owned outpatient department$66.07$63.10 to $93.33

How much rates vary

Facilitymedian $66 · 10th to 90th $51 to $4,266Professionalmedian $66 · 10th to 90th $45 to $120
$100$1K$10K$100Kfacility $66professional $66

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$63.10
Median
$63.10
Typical High
$125.89
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$52.48
Median
$54.95
Typical High
$63.10
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$19.95
Median
$20.42
Typical High
$22.39
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$33.11
Median
$33.88
Typical High
$40.74
Capital Blue Cross
Setting
Facility
Modifier
None
Typical Low
$4,265.80
Median
$5,011.87
Typical High
$79,432.82
Capital Blue Cross
Setting
Facility
Modifier
TC · Technical part
Typical Low
$144.54
Median
$181.97
Typical High
$5,011.87
Capital Blue Cross
Setting
Professional
Modifier
None (both parts)
Typical Low
$64.57
Median
$107.15
Typical High
$181.97
Capital Blue Cross
Setting
Professional
Modifier
26 · Professional part
Typical Low
$24.55
Median
$39.81
Typical High
$67.61
Capital Blue Cross
Setting
Professional
Modifier
TC · Technical part
Typical Low
$39.81
Median
$67.61
Typical High
$114.82
Cigna
Setting
Facility
Modifier
None
Typical Low
$38.90
Median
$69.18
Typical High
$138.04
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$30.20
Median
$58.88
Typical High
$97.72
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$11.75
Median
$21.88
Typical High
$34.67
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$19.05
Median
$38.02
Typical High
$63.10
Emblem Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$47.86
Median
$93.33
Typical High
$93.33
Geisinger
Setting
Professional
Modifier
None (both parts)
Typical Low
$57.54
Median
$69.18
Typical High
$131.83
Geisinger
Setting
Professional
Modifier
26 · Professional part
Typical Low
$20.89
Median
$26.92
Typical High
$50.12
Geisinger
Setting
Professional
Modifier
TC · Technical part
Typical Low
$36.31
Median
$43.65
Typical High
$81.28
Martin's Point
Setting
Facility
Modifier
None
Typical Low
$63.10
Median
$63.10
Typical High
$125.89
Martin's Point
Setting
Professional
Modifier
None (both parts)
Typical Low
$52.48
Median
$54.95
Typical High
$63.10
Martin's Point
Setting
Professional
Modifier
26 · Professional part
Typical Low
$19.95
Median
$20.42
Typical High
$22.39
Martin's Point
Setting
Professional
Modifier
TC · Technical part
Typical Low
$33.11
Median
$33.88
Typical High
$40.74
UPMC Health Plan
Setting
Facility
Modifier
None
Typical Low
$63.10
Median
$63.10
Typical High
$66.07
UPMC Health Plan
Setting
Professional
Modifier
None (both parts)
Typical Low
$63.10
Median
$63.10
Typical High
$66.07
UPMC Health Plan
Setting
Professional
Modifier
26 · Professional part
Typical Low
$22.91
Median
$22.91
Typical High
$24.55
UPMC Health Plan
Setting
Professional
Modifier
TC · Technical part
Typical Low
$39.81
Median
$39.81
Typical High
$41.69
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$39.81
Median
$69.18
Typical High
$112.20
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$15.14
Median
$26.30
Typical High
$40.74
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$24.55
Median
$44.67
Typical High
$70.79
5 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$26.30
Median
$26.92
Typical High
$31.62
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$10.72
Median
$10.96
Typical High
$12.59
Highmark BCBS
Setting
Facility
Modifier
XU · Unusual separate service
Typical Low
$56.23
Median
$56.23
Typical High
$56.23
Martin's Point
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$26.30
Median
$26.92
Typical High
$31.62
Martin's Point
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$10.72
Median
$10.96
Typical High
$12.59

Where Pennsylvania sits

The same service costs 4.4 times more in Alaska than in Texas. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Pennsylvania· 30th of 51

$66.07

AK $182TX $41.69

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.