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In Situ Hybridization Analysis of Tissue

Minnesota rates for HCPCS 88373

A laboratory analysis in which a piece of tissue is treated with a labeled probe that sticks to one specific stretch of genetic material, and the amount present is then measured. It is performed on a sample already being examined by a pathologist and is reported in addition to that examination.

Rates data updated October 2026.

How much does In Situ Hybridization Analysis of Tissue cost?

$110

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $110 for this service. The price depends on where it is billed: about $110 from a physician practice, and about $120 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$110$87.10 to $174
FacilityA hospital or hospital-owned outpatient department$120$60.26 to $214

How much rates vary

Facilitymedian $120 · 10th to 90th $60 to $288Professionalmedian $110 · 10th to 90th $60 to $229
$50$100$200$500facility $120professional $110

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$60.26
Median
$60.26
Typical High
$60.26
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$22.39
Median
$22.39
Typical High
$22.39
Aetna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$38.02
Median
$38.02
Typical High
$38.02
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$60.26
Median
$60.26
Typical High
$60.26
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$22.39
Median
$22.39
Typical High
$22.39
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$38.02
Median
$38.02
Typical High
$38.02
BCBS Minnesota
Setting
Facility
Modifier
None
Typical Low
$104.71
Median
$151.36
Typical High
$239.88
BCBS Minnesota
Setting
Professional
Modifier
None (both parts)
Typical Low
$89.13
Median
$154.88
Typical High
$239.88
BCBS Minnesota
Setting
Professional
Modifier
26 · Professional part
Typical Low
$33.11
Median
$57.54
Typical High
$89.13
BCBS Minnesota
Setting
Professional
Modifier
TC · Technical part
Typical Low
$54.95
Median
$100.00
Typical High
$151.36
Cigna
Setting
Facility
Modifier
None
Typical Low
$144.54
Median
$229.09
Typical High
$660.69
Cigna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$53.70
Median
$83.18
Typical High
$245.47
Cigna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$91.20
Median
$144.54
Typical High
$426.58
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$87.10
Median
$95.50
Typical High
$128.82
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$32.36
Median
$35.48
Typical High
$46.77
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$54.95
Median
$60.26
Typical High
$81.28
Health Partners
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$218.78
Typical High
$524.81
Health Partners
Setting
Facility
Modifier
26 · Professional part
Typical Low
$48.98
Median
$81.28
Typical High
$194.98
Health Partners
Setting
Facility
Modifier
TC · Technical part
Typical Low
$85.11
Median
$141.25
Typical High
$331.13
Health Partners
Setting
Professional
Modifier
None (both parts)
Typical Low
$87.10
Median
$87.10
Typical High
$123.03
Health Partners
Setting
Professional
Modifier
26 · Professional part
Typical Low
$31.62
Median
$31.62
Typical High
$44.67
Health Partners
Setting
Professional
Modifier
TC · Technical part
Typical Low
$54.95
Median
$54.95
Typical High
$77.62
Medica
Setting
Facility
Modifier
None
Typical Low
$93.33
Median
$112.20
Typical High
$128.82
Medica
Setting
Professional
Modifier
None (both parts)
Typical Low
$64.57
Median
$158.49
Typical High
$436.52
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$22.91
Median
$58.88
Typical High
$158.49
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$41.69
Median
$100.00
Typical High
$281.84
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$44.67
Median
$144.54
Typical High
$218.78
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$16.60
Median
$51.29
Typical High
$81.28
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$28.18
Median
$93.33
Typical High
$138.04
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$30.20
Median
$30.20
Typical High
$30.20
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$12.02
Median
$12.02
Typical High
$12.02
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$30.20
Median
$30.20
Typical High
$30.20
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$12.02
Median
$12.02
Typical High
$12.02

Where Minnesota sits

The same service costs 4.4 times more in Alaska than in Texas. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 8th of 51

$110

AK $182TX $41.69

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.