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Computer-Assisted Tissue Stain Measurement

Massachusetts rates for HCPCS 88361

A pathologist uses image-analysis software to measure how strongly a single special stain lit up in a tissue sample taken during a biopsy or surgery, such as a hormone-receptor or growth-protein marker used to guide cancer treatment. The computer assistance gives a more precise, repeatable score than reading the slide by eye alone. It is typically done after a tumor sample has already been stained, to help decide which therapies are likely to work.

Rates data updated October 2026.

How much does Computer-Assisted Tissue Stain Measurement cost?

$158

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $158 for this service. The price depends on where it is billed: about $162 from a physician practice, and about $132 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$162$112 to $324
FacilityA hospital or hospital-owned outpatient department$132$93.33 to $316

How much rates vary

Facilitymedian $132 · 10th to 90th $56 to $490Professionalmedian $162 · 10th to 90th $66 to $912
$50$100$200$500$1K$2K$5Kfacility $132professional $162

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$134.90
Typical High
$549.54
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$128.82
Median
$134.90
Typical High
$549.54
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$44.67
Median
$44.67
Typical High
$190.55
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$81.28
Median
$89.13
Typical High
$363.08
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$131.83
Median
$416.87
Typical High
$478.63
AllWays Health Partners
Setting
Professional
Modifier
None (both parts)
Typical Low
$91.20
Median
$338.84
Typical High
$912.01
AllWays Health Partners
Setting
Professional
Modifier
26 · Professional part
Typical Low
$39.81
Median
$114.82
Typical High
$363.08
AllWays Health Partners
Setting
Professional
Modifier
TC · Technical part
Typical Low
$74.13
Median
$234.42
Typical High
$562.34
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$316.23
Median
$436.52
Typical High
$630.96
BCBS Massachusetts
Setting
Professional
Modifier
None (both parts)
Typical Low
$134.90
Median
$138.04
Typical High
$165.96
BCBS Massachusetts
Setting
Professional
Modifier
26 · Professional part
Typical Low
$44.67
Median
$44.67
Typical High
$77.62
Cigna
Setting
Facility
Modifier
None
Typical Low
$60.26
Median
$120.23
Typical High
$281.84
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$64.57
Median
$158.49
Typical High
$309.03
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$21.88
Median
$57.54
Typical High
$102.33
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$42.66
Median
$107.15
Typical High
$204.17
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$53.70
Median
$112.20
Typical High
$190.55
Fallon Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$54.95
Median
$120.23
Typical High
$190.55
Harvard Pilgrim
Setting
Professional
Modifier
None (both parts)
Typical Low
$89.13
Median
$223.87
Typical High
$363.08
Harvard Pilgrim
Setting
Professional
Modifier
26 · Professional part
Typical Low
$36.31
Median
$83.18
Typical High
$125.89
Harvard Pilgrim
Setting
Professional
Modifier
TC · Technical part
Typical Low
$67.61
Median
$154.88
Typical High
$234.42
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$131.83
Median
$416.87
Typical High
$478.63
Mass General Brigham
Setting
Professional
Modifier
None (both parts)
Typical Low
$91.20
Median
$338.84
Typical High
$912.01
Mass General Brigham
Setting
Professional
Modifier
26 · Professional part
Typical Low
$39.81
Median
$114.82
Typical High
$363.08
Mass General Brigham
Setting
Professional
Modifier
TC · Technical part
Typical Low
$74.13
Median
$234.42
Typical High
$562.34
United
Setting
Facility
Modifier
None
Typical Low
$501.19
Median
$954.99
Typical High
$1,412.54
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$89.13
Median
$147.91
Typical High
$354.81
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.20
Median
$50.12
Typical High
$117.49
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$58.88
Median
$91.20
Typical High
$239.88
Well Sense
Setting
Facility
Modifier
None
Typical Low
$91.20
Median
$125.89
Typical High
$190.55
Well Sense
Setting
Facility
Modifier
26 · Professional part
Typical Low
$31.62
Median
$41.69
Typical High
$74.13
Well Sense
Setting
Facility
Modifier
TC · Technical part
Typical Low
$60.26
Median
$77.62
Typical High
$141.25
Well Sense
Setting
Professional
Modifier
None (both parts)
Typical Low
$117.49
Median
$117.49
Typical High
$138.04
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$66.07
Median
$66.07
Typical High
$275.42
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$26.92
Median
$26.92
Typical High
$109.65

Where Massachusetts sits

The same service costs 4.5 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 17th of 51

$158

AK $316AL $70.79

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.