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Additional Special Marker Stain On A Tissue Sample

North Carolina rates for HCPCS 88341

This covers an additional specialized stain applied to a tissue sample to detect a specific marker, beyond the first such stain already performed. These stains use targeted markers to help identify particular cell types or characteristics that support a diagnosis, often for conditions like cancer.

Rates data updated October 2026.

How much does Additional Special Marker Stain On A Tissue Sample cost?

$81.28

Typical negotiated rate. In North Carolina, October 2026.

Insurers have agreed to pay about $81.28 for this service. The price depends on where it is billed: about $81.28 from a physician practice, and about $95.50 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$81.28$52.48 to $95.50
FacilityA hospital or hospital-owned outpatient department$95.50$67.61 to $148

How much rates vary

Facilitymedian $95 · 10th to 90th $68 to $302Professionalmedian $81 · 10th to 90th $34 to $148
$50$100$200facility $95professional $81

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$67.61
Median
$67.61
Typical High
$120.23
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$21.88
Median
$21.88
Typical High
$37.15
Aetna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$45.71
Median
$45.71
Typical High
$83.18
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$63.10
Median
$67.61
Typical High
$177.83
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$20.42
Median
$21.88
Typical High
$46.77
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$43.65
Median
$45.71
Typical High
$120.23
Ambetter
Setting
Professional
Modifier
None (both parts)
Typical Low
$44.67
Median
$44.67
Typical High
$162.18
BCBS North Carolina
Setting
Facility
Modifier
None
Typical Low
$234.42
Median
$234.42
Typical High
$234.42
BCBS North Carolina
Setting
Professional
Modifier
26 · Professional part
Typical Low
$25.70
Median
$41.69
Typical High
$56.23
BCBS North Carolina
Setting
Professional
Modifier
TC · Technical part
Typical Low
$56.23
Median
$58.88
Typical High
$109.65
Cigna
Setting
Facility
Modifier
None
Typical Low
$51.29
Median
$147.91
Typical High
$302.00
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$33.88
Median
$43.65
Typical High
$138.04
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$11.22
Median
$13.80
Typical High
$40.74
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$22.39
Median
$29.51
Typical High
$79.43
Medcost
Setting
Facility
Modifier
None
Typical Low
$67.61
Median
$67.61
Typical High
$104.71
Medcost
Setting
Professional
Modifier
None (both parts)
Typical Low
$95.50
Median
$95.50
Typical High
$107.15
Medcost
Setting
Professional
Modifier
26 · Professional part
Typical Low
$31.62
Median
$31.62
Typical High
$38.90
Medcost
Setting
Professional
Modifier
TC · Technical part
Typical Low
$63.10
Median
$63.10
Typical High
$72.44
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$48.98
Median
$64.57
Typical High
$158.49
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$15.49
Median
$21.38
Typical High
$50.12
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$30.20
Median
$42.66
Typical High
$109.65
7 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$31.62
Median
$33.88
Typical High
$40.74
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$12.59
Median
$13.49
Typical High
$16.22
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$47.86
Median
$47.86
Typical High
$77.62
Medcost
Setting
Professional
Modifier
80 · Assistant surgeon
Typical Low
$19.05
Median
$19.05
Typical High
$30.90
Medcost
Setting
Professional
Modifier
81 · Minimal assistant surgeon
Typical Low
$13.49
Median
$13.49
Typical High
$21.38
Medcost
Setting
Professional
Modifier
82 · Assistant surgeon, no resident
Typical Low
$13.49
Median
$13.49
Typical High
$21.38
Medcost
Setting
Professional
Modifier
AS · PA/NP assist
Typical Low
$13.49
Median
$13.49
Typical High
$21.38

Where North Carolina sits

The same service costs 5.9 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 36th of 51

$81.28

AK $347AL $58.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.