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Additional Special Marker Stain On A Tissue Sample

Minnesota rates for HCPCS 88341

This covers an additional specialized stain applied to a tissue sample to detect a specific marker, beyond the first such stain already performed. These stains use targeted markers to help identify particular cell types or characteristics that support a diagnosis, often for conditions like cancer.

Rates data updated October 2026.

How much does Additional Special Marker Stain On A Tissue Sample cost?

$182

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $182 for this service. The price depends on where it is billed: about $162 from a physician practice, and about $186 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$162$129 to $245
FacilityA hospital or hospital-owned outpatient department$186$91.20 to $229

How much rates vary

Facilitymedian $186 · 10th to 90th $85 to $363Professionalmedian $162 · 10th to 90th $89 to $331
$50$100$200$500facility $186professional $162

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$89.13
Median
$186.21
Typical High
$363.08
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$25.12
Median
$25.12
Typical High
$26.30
Aetna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$64.57
Median
$64.57
Typical High
$64.57
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$69.18
Median
$89.13
Typical High
$186.21
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$21.38
Median
$25.12
Typical High
$39.81
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$46.77
Median
$64.57
Typical High
$97.72
BCBS Minnesota
Setting
Facility
Modifier
None
Typical Low
$95.50
Median
$125.89
Typical High
$295.12
BCBS Minnesota
Setting
Professional
Modifier
None (both parts)
Typical Low
$131.83
Median
$218.78
Typical High
$354.81
BCBS Minnesota
Setting
Professional
Modifier
26 · Professional part
Typical Low
$37.15
Median
$64.57
Typical High
$100.00
BCBS Minnesota
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$162.18
Typical High
$251.19
Cigna
Setting
Facility
Modifier
None
Typical Low
$213.80
Median
$338.84
Typical High
$977.24
Cigna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$60.26
Median
$95.50
Typical High
$275.42
Cigna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$154.88
Median
$245.47
Typical High
$707.95
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$128.82
Median
$141.25
Typical High
$190.55
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$36.31
Median
$39.81
Typical High
$52.48
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$102.33
Typical High
$138.04
Health Partners
Setting
Facility
Modifier
None
Typical Low
$199.53
Median
$323.59
Typical High
$776.25
Health Partners
Setting
Facility
Modifier
26 · Professional part
Typical Low
$54.95
Median
$91.20
Typical High
$218.78
Health Partners
Setting
Facility
Modifier
TC · Technical part
Typical Low
$144.54
Median
$234.42
Typical High
$562.34
Health Partners
Setting
Professional
Modifier
None (both parts)
Typical Low
$128.82
Median
$128.82
Typical High
$181.97
Health Partners
Setting
Professional
Modifier
26 · Professional part
Typical Low
$35.48
Median
$35.48
Typical High
$50.12
Health Partners
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$93.33
Typical High
$131.83
Medica
Setting
Facility
Modifier
None
Typical Low
$40.74
Median
$120.23
Typical High
$275.42
Medica
Setting
Facility
Modifier
TC · Technical part
Typical Low
$50.12
Median
$177.83
Typical High
$229.09
Medica
Setting
Professional
Modifier
None (both parts)
Typical Low
$89.13
Median
$169.82
Typical High
$562.34
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$47.86
Median
$91.20
Typical High
$131.83
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$58.88
Median
$169.82
Typical High
$389.05
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$56.23
Median
$165.96
Typical High
$275.42
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$17.78
Median
$53.70
Typical High
$87.10
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$38.90
Median
$114.82
Typical High
$190.55
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$44.67
Median
$44.67
Typical High
$44.67
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$17.78
Median
$17.78
Typical High
$17.78
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$44.67
Median
$44.67
Typical High
$44.67
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$17.78
Median
$17.78
Typical High
$17.78

Where Minnesota sits

The same service costs 5.9 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 3rd of 51

$182

AK $347AL $58.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.