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HE4 Tumor Marker Blood Test

South Dakota rates for HCPCS 86305

A blood test that measures human epididymis protein 4, a substance often raised in women with ovarian cancer. It is used together with other tests when assessing a mass on an ovary, and to follow how a known ovarian cancer responds to treatment.

Rates data updated July 2026.

How much does HE4 Tumor Marker Blood Test cost?

$39.81

Typical negotiated rate. In South Dakota, July 2026.

Insurers have agreed to pay about $39.81 for this service. The price depends on where it is billed: about $33.88 from a physician practice, and about $39.81 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$33.88$16.22 to $50.12
FacilityA hospital or hospital-owned outpatient department$39.81$38.02 to $39.81

How much rates vary

Facilitymedian $40 · 10th to 90th $23 to $40Professionalmedian $34 · 10th to 90th $14 to $56
$10$20$50$100facility $40professional $34

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$14.45
Median
$23.44
Typical High
$23.44
Aetna
Setting
Professional
Modifier
Global
Typical Low
$13.80
Median
$16.22
Typical High
$19.50
Cigna
Setting
Facility
Modifier
Global
Typical Low
$39.81
Median
$39.81
Typical High
$39.81
Cigna
Setting
Professional
Modifier
Global
Typical Low
$23.99
Median
$39.81
Typical High
$50.12
Medica
Setting
Facility
Modifier
Global
Typical Low
$19.50
Median
$29.51
Typical High
$100.00
Medica
Setting
Professional
Modifier
Global
Typical Low
$12.59
Median
$14.45
Typical High
$29.51
Sanford Health Plan
Setting
Professional
Modifier
Global
Typical Low
$30.90
Median
$50.12
Typical High
$57.54
United
Setting
Facility
Modifier
Global
Typical Low
$25.12
Median
$25.12
Typical High
$25.12
United
Setting
Professional
Modifier
Global
Typical Low
$8.71
Median
$18.62
Typical High
$36.31
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$20.89
Median
$20.89
Typical High
$20.89

Where South Dakota sits

The same service costs 3.2 times more in Oklahoma than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 2nd of 51

$39.81

OK $50.12DC $15.49

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.