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HE4 Tumor Marker Blood Test

Pennsylvania rates for HCPCS 86305

A blood test that measures human epididymis protein 4, a substance often raised in women with ovarian cancer. It is used together with other tests when assessing a mass on an ovary, and to follow how a known ovarian cancer responds to treatment.

Rates data updated July 2026.

How much does HE4 Tumor Marker Blood Test cost?

$19.50

Typical negotiated rate. In Pennsylvania, July 2026.

Insurers have agreed to pay about $19.50 for this service. The price depends on where it is billed: about $16.98 from a physician practice, and about $47.86 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$16.98$16.60 to $19.50
FacilityA hospital or hospital-owned outpatient department$47.86$25.12 to $61.66

How much rates vary

Facilitymedian $48 · 10th to 90th $18 to $95Professionalmedian $17 · 10th to 90th $16 to $37
$10$20$50$100$200facility $48professional $17

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$17.78
Median
$48.98
Typical High
$77.62
Aetna
Setting
Professional
Modifier
Global
Typical Low
$16.22
Median
$16.98
Typical High
$48.98
Capital Blue Cross
Setting
Facility
Modifier
Global
Typical Low
$107.15
Median
$147.91
Typical High
$8,511.38
Capital Blue Cross
Setting
Professional
Modifier
Global
Typical Low
$16.22
Median
$16.22
Typical High
$20.42
Cigna
Setting
Facility
Modifier
Global
Typical Low
$15.14
Median
$31.62
Typical High
$70.79
Cigna
Setting
Professional
Modifier
Global
Typical Low
$12.02
Median
$28.84
Typical High
$53.70
Emblem Health
Setting
Professional
Modifier
Global
Typical Low
$9.77
Median
$20.89
Typical High
$30.20
Geisinger
Setting
Facility
Modifier
Global
Typical Low
$20.89
Median
$20.89
Typical High
$20.89
Geisinger
Setting
Professional
Modifier
Global
Typical Low
$17.78
Median
$22.39
Typical High
$36.31
Highmark BCBS
Setting
Facility
Modifier
Global
Typical Low
$128.82
Median
$128.82
Typical High
$128.82
Martin's Point
Setting
Facility
Modifier
Global
Typical Low
$16.98
Median
$52.48
Typical High
$77.62
Martin's Point
Setting
Professional
Modifier
Global
Typical Low
$16.22
Median
$17.78
Typical High
$61.66
UPMC Health Plan
Setting
Facility
Modifier
Global
Typical Low
$40.74
Median
$83.18
Typical High
$173.78
UPMC Health Plan
Setting
Professional
Modifier
Global
Typical Low
$18.20
Median
$26.92
Typical High
$26.92
United
Setting
Facility
Modifier
Global
Typical Low
$11.48
Median
$20.89
Typical High
$25.12
United
Setting
Professional
Modifier
Global
Typical Low
$9.33
Median
$14.79
Typical High
$35.48

Where Pennsylvania sits

The same service costs 3.2 times more in Oklahoma than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Pennsylvania· 34th of 51

$19.50

OK $50.12DC $15.49

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.