go back

HE4 Tumor Marker Blood Test

Missouri rates for HCPCS 86305

A blood test that measures human epididymis protein 4, a substance often raised in women with ovarian cancer. It is used together with other tests when assessing a mass on an ovary, and to follow how a known ovarian cancer responds to treatment.

Rates data updated July 2026.

How much does HE4 Tumor Marker Blood Test cost?

$20.89

Typical negotiated rate. In Missouri, July 2026.

Insurers have agreed to pay about $20.89 for this service. The price depends on where it is billed: about $18.20 from a physician practice, and about $28.84 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$18.20$12.59 to $26.30
FacilityA hospital or hospital-owned outpatient department$28.84$20.89 to $36.31

How much rates vary

Facilitymedian $29 · 10th to 90th $20 to $48Professionalmedian $18 · 10th to 90th $10 to $41
$10$20$50$100facility $29professional $18

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$20.42
Median
$34.67
Typical High
$47.86
Aetna
Setting
Professional
Modifier
Global
Typical Low
$17.78
Median
$20.42
Typical High
$34.67
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$20.89
Median
$20.89
Typical High
$72.44
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$10.23
Median
$17.78
Typical High
$52.48
Cigna
Setting
Facility
Modifier
Global
Typical Low
$27.54
Median
$40.74
Typical High
$117.49
Cigna
Setting
Professional
Modifier
Global
Typical Low
$10.96
Median
$18.20
Typical High
$35.48
Medica
Setting
Facility
Modifier
Global
Typical Low
$18.62
Median
$36.31
Typical High
$100.00
Medica
Setting
Professional
Modifier
Global
Typical Low
$8.71
Median
$12.59
Typical High
$25.12
United
Setting
Facility
Modifier
Global
Typical Low
$12.02
Median
$20.89
Typical High
$27.54
United
Setting
Professional
Modifier
Global
Typical Low
$8.71
Median
$12.59
Typical High
$26.92

Where Missouri sits

The same service costs 3.2 times more in Oklahoma than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 25th of 51

$20.89

OK $50.12DC $15.49

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.