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HE4 Tumor Marker Blood Test

Massachusetts rates for HCPCS 86305

A blood test that measures human epididymis protein 4, a substance often raised in women with ovarian cancer. It is used together with other tests when assessing a mass on an ovary, and to follow how a known ovarian cancer responds to treatment.

Rates data updated July 2026.

How much does HE4 Tumor Marker Blood Test cost?

$21.88

Typical negotiated rate. In Massachusetts, July 2026.

Insurers have agreed to pay about $21.88 for this service. The price depends on where it is billed: about $20.89 from a physician practice, and about $51.29 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$20.89$19.95 to $25.12
FacilityA hospital or hospital-owned outpatient department$51.29$29.51 to $63.10

How much rates vary

Facilitymedian $51 · 10th to 90th $20 to $81Professionalmedian $21 · 10th to 90th $18 to $49
$10$50$200$1Kfacility $51professional $21

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$19.95
Median
$47.86
Typical High
$89.13
Aetna
Setting
Professional
Modifier
Global
Typical Low
$18.62
Median
$19.95
Typical High
$23.99
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$19.05
Median
$29.51
Typical High
$100.00
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$12.59
Median
$20.89
Typical High
$50.12
BCBS
Setting
Facility
Modifier
Global
Typical Low
$40.74
Median
$51.29
Typical High
$72.44
Cigna
Setting
Facility
Modifier
Global
Typical Low
$16.22
Median
$33.88
Typical High
$53.70
Cigna
Setting
Professional
Modifier
Global
Typical Low
$12.88
Median
$24.55
Typical High
$53.70
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$23.99
Median
$162.18
Typical High
$7,079.46
Fallon Health
Setting
Professional
Modifier
Global
Typical Low
$30.20
Median
$30.20
Typical High
$35.48
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$20.89
Median
$20.89
Typical High
$63.10
Health New England
Setting
Facility
Modifier
Global
Typical Low
$24.55
Median
$24.55
Typical High
$46.77
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$19.05
Median
$29.51
Typical High
$100.00
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$12.59
Median
$20.89
Typical High
$50.12
United
Setting
Facility
Modifier
Global
Typical Low
$12.02
Median
$20.89
Typical High
$29.51
United
Setting
Professional
Modifier
Global
Typical Low
$12.59
Median
$19.50
Typical High
$56.23

Where Massachusetts sits

The same service costs 3.2 times more in Oklahoma than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 23rd of 51

$21.88

OK $50.12DC $15.49

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.