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HE4 Tumor Marker Blood Test

Florida rates for HCPCS 86305

A blood test that measures human epididymis protein 4, a substance often raised in women with ovarian cancer. It is used together with other tests when assessing a mass on an ovary, and to follow how a known ovarian cancer responds to treatment.

Rates data updated July 2026.

How much does HE4 Tumor Marker Blood Test cost?

$18.62

Typical negotiated rate. In Florida, July 2026.

Insurers have agreed to pay about $18.62 for this service. The price depends on where it is billed: about $17.78 from a physician practice, and about $47.86 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$17.78$16.98 to $19.05
FacilityA hospital or hospital-owned outpatient department$47.86$20.89 to $66.07

How much rates vary

Facilitymedian $48 · 10th to 90th $19 to $100Professionalmedian $18 · 10th to 90th $15 to $19
$10$20$50$100facility $48professional $18

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$18.62
Median
$58.88
Typical High
$102.33
Aetna
Setting
Professional
Modifier
Global
Typical Low
$16.98
Median
$17.78
Typical High
$19.05
Ambetter
Setting
Professional
Modifier
Global
Typical Low
$12.59
Median
$12.88
Typical High
$12.88
AvMed
Setting
Facility
Modifier
Global
Typical Low
$18.20
Median
$20.89
Typical High
$24.55
AvMed
Setting
Professional
Modifier
Global
Typical Low
$16.60
Median
$20.89
Typical High
$25.12
Cigna
Setting
Facility
Modifier
Global
Typical Low
$14.45
Median
$25.70
Typical High
$60.26
Cigna
Setting
Professional
Modifier
Global
Typical Low
$10.72
Median
$21.88
Typical High
$41.69
Florida Blue
Setting
Facility
Modifier
Global
Typical Low
$38.90
Median
$38.90
Typical High
$38.90
Florida Blue
Setting
Professional
Modifier
Global
Typical Low
$12.59
Median
$12.59
Typical High
$29.51
United
Setting
Facility
Modifier
Global
Typical Low
$9.33
Median
$18.62
Typical High
$25.70
United
Setting
Professional
Modifier
Global
Typical Low
$8.32
Median
$12.30
Typical High
$29.51
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$10.23
Median
$10.72
Typical High
$20.89

Where Florida sits

The same service costs 3.2 times more in Oklahoma than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Florida· 37th of 51

$18.62

OK $50.12DC $15.49

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.