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HE4 Tumor Marker Blood Test

Colorado rates for HCPCS 86305

A blood test that measures human epididymis protein 4, a substance often raised in women with ovarian cancer. It is used together with other tests when assessing a mass on an ovary, and to follow how a known ovarian cancer responds to treatment.

Rates data updated July 2026.

How much does HE4 Tumor Marker Blood Test cost?

$19.50

Typical negotiated rate. In Colorado, July 2026.

Insurers have agreed to pay about $19.50 for this service. The price depends on where it is billed: about $15.85 from a physician practice, and about $53.70 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$15.85$15.14 to $19.05
FacilityA hospital or hospital-owned outpatient department$53.70$27.54 to $87.10

How much rates vary

Facilitymedian $54 · 10th to 90th $16 to $105Professionalmedian $16 · 10th to 90th $9 to $20
$10$20$50$100facility $54professional $16

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$13.18
Median
$45.71
Typical High
$97.72
Aetna
Setting
Professional
Modifier
Global
Typical Low
$15.85
Median
$15.85
Typical High
$19.95
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$26.30
Median
$61.66
Typical High
$104.71
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$8.71
Median
$8.71
Typical High
$15.85
Cigna
Setting
Facility
Modifier
Global
Typical Low
$12.02
Median
$14.45
Typical High
$54.95
Cigna
Setting
Professional
Modifier
Global
Typical Low
$10.72
Median
$13.80
Typical High
$25.12
Denver HMP
Setting
Facility
Modifier
Global
Typical Low
$15.85
Median
$20.89
Typical High
$38.02
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$29.51
Median
$380.19
Typical High
$380.19
Select Health
Setting
Facility
Modifier
Global
Typical Low
$21.88
Median
$38.90
Typical High
$43.65
Select Health
Setting
Professional
Modifier
Global
Typical Low
$14.45
Median
$14.45
Typical High
$20.89
United
Setting
Facility
Modifier
Global
Typical Low
$15.85
Median
$20.89
Typical High
$30.90
United
Setting
Professional
Modifier
Global
Typical Low
$8.71
Median
$12.30
Typical High
$19.50

Where Colorado sits

The same service costs 3.2 times more in Oklahoma than in Washington, DC. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 31st of 51

$19.50

OK $50.12DC $15.49

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.