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Clotting-regulation Protein Blood Test, Protein S

Massachusetts rates for HCPCS 85306

This is a blood test that measures protein S, one of the body's natural proteins that helps keep blood clotting properly balanced. It's typically ordered as part of a work-up after an unexplained or recurrent blood clot, to check whether a deficiency in this protein might be a contributing factor. It's usually run together with a small set of related clot-regulation tests.

Rates data updated July 2026.

How much does Clotting-regulation Protein Blood Test, Protein S cost?

$18.20

Typical negotiated rate. In Massachusetts, July 2026.

Insurers have agreed to pay about $18.20 for this service. The price depends on where it is billed: about $15.49 from a physician practice, and about $43.65 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$15.49$13.80 to $16.22
FacilityA hospital or hospital-owned outpatient department$43.65$26.30 to $107

How much rates vary

Facilitymedian $44 · 10th to 90th $15 to $200Professionalmedian $15 · 10th to 90th $13 to $35
$10$20$50$100$200facility $44professional $15

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$15.49
Median
$46.77
Typical High
$275.42
Aetna
Setting
Professional
Modifier
Global
Typical Low
$13.49
Median
$13.80
Typical High
$28.84
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$14.13
Median
$21.38
Typical High
$208.93
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$9.12
Median
$15.49
Typical High
$37.15
BCBS
Setting
Facility
Modifier
Global
Typical Low
$29.51
Median
$37.15
Typical High
$53.70
BCBS
Setting
Professional
Modifier
Global
Typical Low
$14.45
Median
$14.45
Typical High
$18.20
Cigna
Setting
Facility
Modifier
Global
Typical Low
$12.02
Median
$23.99
Typical High
$39.81
Cigna
Setting
Professional
Modifier
Global
Typical Low
$9.33
Median
$17.38
Typical High
$39.81
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$16.22
Median
$114.82
Typical High
$7,079.46
Fallon Health
Setting
Professional
Modifier
Global
Typical Low
$21.88
Median
$21.88
Typical High
$25.70
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$15.49
Median
$15.49
Typical High
$43.65
Health New England
Setting
Facility
Modifier
Global
Typical Low
$18.62
Median
$32.36
Typical High
$169.82
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$14.13
Median
$21.38
Typical High
$208.93
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$9.12
Median
$15.49
Typical High
$37.15
United
Setting
Facility
Modifier
Global
Typical Low
$8.71
Median
$15.49
Typical High
$22.39
United
Setting
Professional
Modifier
Global
Typical Low
$9.12
Median
$13.80
Typical High
$38.90

Where Massachusetts sits

The same service costs 3.6 times more in West Virginia than in Kentucky. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 30th of 51

$18.20

WV $50.12KY $13.80

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.