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Enzyme Activity Test, Blood or Tissue

South Dakota rates for HCPCS 82657

This is a laboratory test that measures how active a specific enzyme is in a blood, cell, or tissue sample, used when a more common, individually named enzyme test does not apply. It can help diagnose or monitor certain metabolic or inherited conditions where a particular enzyme is missing or not working properly.

Rates data updated October 2026.

How much does Enzyme Activity Test, Blood or Tissue cost?

$25.70

Typical negotiated rate. In South Dakota, October 2026.

Insurers have agreed to pay about $25.70 for this service. The price depends on where it is billed: about $25.70 from a physician practice, and about $40.74 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$25.70$14.79 to $42.66
FacilityA hospital or hospital-owned outpatient department$40.74$25.12 to $69.18

How much rates vary

Facilitymedian $41 · 10th to 90th $25 to $550Professionalmedian $26 · 10th to 90th $13 to $54
$10$20$50$100$200$500$1Kfacility $41professional $26

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$15.49
Median
$15.49
Typical High
$25.12
Aetna
Setting
Professional
Modifier
None
Typical Low
$14.79
Median
$14.79
Typical High
$20.89
Cigna
Setting
Facility
Modifier
None
Typical Low
$42.66
Median
$42.66
Typical High
$42.66
Cigna
Setting
Professional
Modifier
None
Typical Low
$25.70
Median
$42.66
Typical High
$53.70
Medica
Setting
Facility
Modifier
None
Typical Low
$25.12
Median
$27.54
Typical High
$741.31
Medica
Setting
Professional
Modifier
None
Typical Low
$12.59
Median
$19.95
Typical High
$26.30
Sanford Health Plan
Setting
Professional
Modifier
None
Typical Low
$33.11
Median
$48.98
Typical High
$60.26
United
Setting
Professional
Modifier
None
Typical Low
$9.33
Median
$13.18
Typical High
$25.12
Wellmark
Setting
Professional
Modifier
None
Typical Low
$22.39
Median
$22.39
Typical High
$22.39

Where South Dakota sits

The same service costs 5.0 times more in Alaska than in Georgia. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 14th of 51

$25.70

AK $50.12GA $10.00

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.