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Enzyme Activity Test, Blood or Tissue

South Dakota rates for HCPCS 82657

This is a laboratory test that measures how active a specific enzyme is in a blood, cell, or tissue sample, used when a more common, individually named enzyme test does not apply. It can help diagnose or monitor certain metabolic or inherited conditions where a particular enzyme is missing or not working properly.

Rates data updated July 2026.

How much does Enzyme Activity Test, Blood or Tissue cost?

$42.66

Typical negotiated rate. In South Dakota, July 2026.

Insurers have agreed to pay about $42.66 for this service. The price depends on where it is billed: about $22.39 from a physician practice, and about $195 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$22.39$16.22 to $48.98
FacilityA hospital or hospital-owned outpatient department$195$195 to $229

How much rates vary

Facilitymedian $195 · 10th to 90th $43 to $398Professionalmedian $22 · 10th to 90th $15 to $54
$10.0$20.0$50.0$100.0$200.0$500.0$1.0Kfacility $195professional $22

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$194.98
Median
$194.98
Typical High
$398.11
Aetna
Setting
Professional
Modifier
Global
Typical Low
$14.79
Median
$16.22
Typical High
$20.89
Avera
Setting
Facility
Modifier
Global
Typical Low
$20.42
Median
$22.39
Typical High
$33.11
Cigna
Setting
Facility
Modifier
Global
Typical Low
$42.66
Median
$42.66
Typical High
$42.66
Cigna
Setting
Professional
Modifier
Global
Typical Low
$25.70
Median
$42.66
Typical High
$53.70
Medica
Setting
Facility
Modifier
Global
Typical Low
$21.38
Median
$61.66
Typical High
$776.25
Medica
Setting
Professional
Modifier
Global
Typical Low
$12.59
Median
$12.59
Typical High
$26.30
Sanford Health Plan
Setting
Professional
Modifier
Global
Typical Low
$31.62
Median
$48.98
Typical High
$60.26
United
Setting
Facility
Modifier
Global
Typical Low
$26.30
Median
$26.30
Typical High
$26.30
United
Setting
Professional
Modifier
Global
Typical Low
$9.33
Median
$19.95
Typical High
$29.51
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$22.39
Median
$22.39
Typical High
$22.39

Where South Dakota sits

The same service costs 3.5 times more in Iowa than in Maryland. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

South Dakota $42.66 · 6th of 51
IA $58.88MD $16.60

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.