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Enzyme Activity Test, Blood or Tissue

South Carolina rates for HCPCS 82657

This is a laboratory test that measures how active a specific enzyme is in a blood, cell, or tissue sample, used when a more common, individually named enzyme test does not apply. It can help diagnose or monitor certain metabolic or inherited conditions where a particular enzyme is missing or not working properly.

Rates data updated October 2026.

How much does Enzyme Activity Test, Blood or Tissue cost?

$27.54

Typical negotiated rate. In South Carolina, October 2026.

Insurers have agreed to pay about $27.54 for this service. The price depends on where it is billed: about $22.39 from a physician practice, and about $58.88 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$22.39$19.95 to $35.48
FacilityA hospital or hospital-owned outpatient department$58.88$44.67 to $107

How much rates vary

Facilitymedian $59 · 10th to 90th $23 to $380Professionalmedian $22 · 10th to 90th $13 to $45
$10$20$50$100$200$500facility $59professional $22

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$17.38
Median
$17.38
Typical High
$35.48
Aetna
Setting
Professional
Modifier
None
Typical Low
$17.38
Median
$17.38
Typical High
$19.95
BCBS South Carolina
Setting
Facility
Modifier
None
Typical Low
$33.88
Median
$64.57
Typical High
$446.68
BCBS South Carolina
Setting
Professional
Modifier
None
Typical Low
$19.95
Median
$22.39
Typical High
$44.67
Cigna
Setting
Facility
Modifier
None
Typical Low
$41.69
Median
$56.23
Typical High
$138.04
Cigna
Setting
Professional
Modifier
None
Typical Low
$10.23
Median
$11.75
Typical High
$26.92
Medcost
Setting
Facility
Modifier
None
Typical Low
$15.49
Median
$23.44
Typical High
$131.83
Medcost
Setting
Professional
Modifier
None
Typical Low
$19.95
Median
$30.90
Typical High
$33.11
United
Setting
Facility
Modifier
None
Typical Low
$19.95
Median
$19.95
Typical High
$26.30
United
Setting
Professional
Modifier
None
Typical Low
$9.33
Median
$13.18
Typical High
$26.30
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$8.71
Median
$8.71
Typical High
$8.91
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$3.47
Median
$3.47
Typical High
$3.55

Where South Carolina sits

The same service costs 5.0 times more in Alaska than in Georgia. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 11th of 51

$27.54

AK $50.12GA $10.00

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.