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Enzyme Activity Test, Blood or Tissue

Maryland rates for HCPCS 82657

This is a laboratory test that measures how active a specific enzyme is in a blood, cell, or tissue sample, used when a more common, individually named enzyme test does not apply. It can help diagnose or monitor certain metabolic or inherited conditions where a particular enzyme is missing or not working properly.

Rates data updated July 2026.

How much does Enzyme Activity Test, Blood or Tissue cost?

$16.60

Typical negotiated rate. In Maryland, July 2026.

Insurers have agreed to pay about $16.60 for this service. The price depends on where it is billed: about $16.60 from a physician practice, and about $93.33 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$16.60$16.22 to $25.70
FacilityA hospital or hospital-owned outpatient department$93.33$26.30 to $97.72

How much rates vary

Facilitymedian $93 · 10th to 90th $14 to $123Professionalmedian $17 · 10th to 90th $13 to $71
$10.0$20.0$50.0$100.0facility $93professional $17

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$16.60
Median
$95.50
Typical High
$131.83
Aetna
Setting
Professional
Modifier
Global
Typical Low
$14.79
Median
$16.60
Typical High
$70.79
CareFirst
Setting
Professional
Modifier
Global
Typical Low
$5.50
Median
$17.78
Typical High
$21.88
Cigna
Setting
Facility
Modifier
Global
Typical Low
$11.75
Median
$14.45
Typical High
$28.84
Cigna
Setting
Professional
Modifier
Global
Typical Low
$11.75
Median
$21.38
Typical High
$54.95
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$22.39
Median
$26.30
Typical High
$37.15
United
Setting
Facility
Modifier
Global
Typical Low
$9.33
Median
$10.47
Typical High
$16.98
United
Setting
Professional
Modifier
Global
Typical Low
$10.00
Median
$10.96
Typical High
$20.89
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$8.71
Median
$15.14
Typical High
$33.11

Where Maryland sits

The same service costs 3.5 times more in Iowa than in Maryland. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Maryland $16.60 · 51st of 51
IA $58.88MD $16.60

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.