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Enzyme Activity Test, Blood or Tissue

Massachusetts rates for HCPCS 82657

This is a laboratory test that measures how active a specific enzyme is in a blood, cell, or tissue sample, used when a more common, individually named enzyme test does not apply. It can help diagnose or monitor certain metabolic or inherited conditions where a particular enzyme is missing or not working properly.

Rates data updated July 2026.

How much does Enzyme Activity Test, Blood or Tissue cost?

$25.12

Typical negotiated rate. In Massachusetts, July 2026.

Insurers have agreed to pay about $25.12 for this service. The price depends on where it is billed: about $22.39 from a physician practice, and about $48.98 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$22.39$18.62 to $30.90
FacilityA hospital or hospital-owned outpatient department$48.98$32.36 to $79.43

How much rates vary

Facilitymedian $49 · 10th to 90th $20 to $245Professionalmedian $22 · 10th to 90th $16 to $55
$10.0$100.0$1.0K$10.0Kfacility $49professional $22

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$22.39
Median
$64.57
Typical High
$346.74
Aetna
Setting
Professional
Modifier
Global
Typical Low
$16.22
Median
$18.62
Typical High
$81.28
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$16.60
Median
$25.70
Typical High
$158.49
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$12.59
Median
$22.39
Typical High
$53.70
BCBS
Setting
Facility
Modifier
Global
Typical Low
$35.48
Median
$44.67
Typical High
$70.79
BCBS
Setting
Professional
Modifier
Global
Typical Low
$20.89
Median
$20.89
Typical High
$22.91
Cigna
Setting
Facility
Modifier
Global
Typical Low
$15.49
Median
$28.84
Typical High
$46.77
Cigna
Setting
Professional
Modifier
Global
Typical Low
$8.91
Median
$13.80
Typical High
$57.54
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$20.89
Median
$144.54
Typical High
$7,079.46
Fallon Health
Setting
Professional
Modifier
Global
Typical Low
$32.36
Median
$32.36
Typical High
$38.02
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$22.39
Median
$22.39
Typical High
$54.95
Health New England
Setting
Facility
Modifier
Global
Typical Low
$16.22
Median
$24.55
Typical High
$1,412.54
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$16.60
Median
$25.70
Typical High
$158.49
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$12.59
Median
$22.39
Typical High
$53.70
United
Setting
Facility
Modifier
Global
Typical Low
$10.96
Median
$22.39
Typical High
$26.30
United
Setting
Professional
Modifier
Global
Typical Low
$12.59
Median
$20.42
Typical High
$51.29

Where Massachusetts sits

The same service costs 3.5 times more in Iowa than in Maryland. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Massachusetts $25.12 · 28th of 51
IA $58.88MD $16.60

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.