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Enzyme Activity Test, Blood or Tissue

Illinois rates for HCPCS 82657

This is a laboratory test that measures how active a specific enzyme is in a blood, cell, or tissue sample, used when a more common, individually named enzyme test does not apply. It can help diagnose or monitor certain metabolic or inherited conditions where a particular enzyme is missing or not working properly.

Rates data updated October 2026.

How much does Enzyme Activity Test, Blood or Tissue cost?

$16.98

Typical negotiated rate. In Illinois, October 2026.

Insurers have agreed to pay about $16.98 for this service. The price depends on where it is billed: about $16.98 from a physician practice, and about $40.74 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$16.98$13.18 to $18.20
FacilityA hospital or hospital-owned outpatient department$40.74$30.20 to $67.61

How much rates vary

Facilitymedian $41 · 10th to 90th $25 to $102Professionalmedian $17 · 10th to 90th $3 to $30
$5$10$20$50$100$200facility $41professional $17

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$19.05
Median
$32.36
Typical High
$66.07
Aetna
Setting
Professional
Modifier
None
Typical Low
$16.60
Median
$18.20
Typical High
$20.89
Ambetter
Setting
Professional
Modifier
None
Typical Low
$13.49
Median
$13.49
Typical High
$13.49
BCBS Illinois
Setting
Facility
Modifier
None
Typical Low
$26.30
Median
$38.90
Typical High
$208.93
BCBS Illinois
Setting
Professional
Modifier
None
Typical Low
$3.47
Median
$16.98
Typical High
$16.98
Cigna
Setting
Facility
Modifier
None
Typical Low
$25.12
Median
$44.67
Typical High
$93.33
Cigna
Setting
Professional
Modifier
None
Typical Low
$10.96
Median
$25.70
Typical High
$38.02
Hally Health
Setting
Professional
Modifier
None
Typical Low
$23.44
Median
$34.67
Typical High
$141.25
Hally Health
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
None
Typical Low
$28.84
Median
$28.84
Typical High
$28.84
Molina
Setting
Professional
Modifier
None
Typical Low
$12.30
Median
$15.49
Typical High
$27.54
United
Setting
Facility
Modifier
None
Typical Low
$22.39
Median
$26.30
Typical High
$27.54
United
Setting
Professional
Modifier
None
Typical Low
$9.33
Median
$14.13
Typical High
$23.99
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$9.12
Median
$16.22
Typical High
$33.88
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$3.63
Median
$6.46
Typical High
$13.49
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$9.12
Median
$9.12
Typical High
$10.96
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$3.63
Median
$3.63
Typical High
$4.47

Where Illinois sits

The same service costs 5.0 times more in Alaska than in Georgia. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Illinois· 45th of 51

$16.98

AK $50.12GA $10.00

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.