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Enzyme Activity Test, Blood or Tissue

Colorado rates for HCPCS 82657

This is a laboratory test that measures how active a specific enzyme is in a blood, cell, or tissue sample, used when a more common, individually named enzyme test does not apply. It can help diagnose or monitor certain metabolic or inherited conditions where a particular enzyme is missing or not working properly.

Rates data updated October 2026.

How much does Enzyme Activity Test, Blood or Tissue cost?

$22.39

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $22.39 for this service. The price depends on where it is billed: about $15.14 from a physician practice, and about $64.57 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$15.14$9.33 to $16.98
FacilityA hospital or hospital-owned outpatient department$64.57$39.81 to $77.62

How much rates vary

Facilitymedian $65 · 10th to 90th $17 to $102Professionalmedian $15 · 10th to 90th $9 to $39
$10$20$50$100facility $65professional $15

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$16.98
Median
$46.77
Typical High
$102.33
Aetna
Setting
Professional
Modifier
None
Typical Low
$14.13
Median
$16.98
Typical High
$22.39
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$25.12
Median
$66.07
Typical High
$102.33
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$9.33
Median
$15.14
Typical High
$45.71
Cigna
Setting
Facility
Modifier
None
Typical Low
$12.88
Median
$26.92
Typical High
$67.61
Cigna
Setting
Professional
Modifier
None
Typical Low
$10.72
Median
$15.14
Typical High
$32.36
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$16.98
Median
$22.91
Typical High
$37.15
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$17.78
Median
$32.36
Typical High
$87.10
Select Health
Setting
Facility
Modifier
None
Typical Low
$22.39
Median
$40.74
Typical High
$46.77
Select Health
Setting
Professional
Modifier
None
Typical Low
$15.49
Median
$15.49
Typical High
$22.39
United
Setting
Facility
Modifier
None
Typical Low
$26.30
Median
$26.30
Typical High
$26.30
United
Setting
Professional
Modifier
None
Typical Low
$9.33
Median
$10.72
Typical High
$16.60
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$8.13
Median
$8.51
Typical High
$10.96
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$3.31
Median
$3.39
Typical High
$4.47

Where Colorado sits

The same service costs 5.0 times more in Alaska than in Georgia. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 23rd of 51

$22.39

AK $50.12GA $10.00

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.