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Gene Activity Test to Identify a Cancer's Origin

Rhode Island rates for HCPCS 81540

A laboratory test on a sample of tumor tissue that measures the activity of a large panel of genes and compares the pattern against the patterns of known cancer types. It is used when a cancer has already spread and doctors cannot tell which organ it began in, because treatment depends on the tissue of origin.

Rates data updated October 2026.

How much does Gene Activity Test to Identify a Cancer's Origin cost?

$2,630

Typical negotiated rate. In Rhode Island, October 2026.

Insurers have agreed to pay about $2,630 for this service. The price depends on where it is billed: about $2,239 from a physician practice, and about $4,365 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 4 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$2,239$2,138 to $2,818
FacilityA hospital or hospital-owned outpatient department$4,365$2,951 to $4,571

How much rates vary

Facilitymedian $4,365 · 10th to 90th $2,630 to $8,913Professionalmedian $2,239 · 10th to 90th $1,660 to $5,012
$2K$5K$10Kfacility $4,365professional $2,239

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$2,137.96
Median
$2,137.96
Typical High
$2,137.96
BCBS Rhode Island
Setting
Facility
Modifier
None
Typical Low
$2,630.27
Median
$4,365.16
Typical High
$4,570.88
BCBS Rhode Island
Setting
Professional
Modifier
None
Typical Low
$2,089.30
Median
$2,818.38
Typical High
$2,818.38
Cigna
Setting
Facility
Modifier
None
Typical Low
$5,128.61
Median
$8,912.51
Typical High
$10,232.93
Cigna
Setting
Professional
Modifier
None
Typical Low
$1,659.59
Median
$5,128.61
Typical High
$5,128.61
United
Setting
Facility
Modifier
None
Typical Low
$4,466.84
Median
$4,466.84
Typical High
$4,466.84
United
Setting
Professional
Modifier
None
Typical Low
$1,513.56
Median
$2,238.72
Typical High
$6,309.57

Where Rhode Island sits

The same service costs 6.5 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Rhode Island· 38th of 51

$2,630

TX $10,233AL $1,585

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.