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Breast Cancer Gene Activity Recurrence Score

South Carolina rates for HCPCS 81521

A laboratory test on a sample of breast cancer tissue that measures the activity of a panel of genes and combines the results into a score estimating how likely the cancer is to come back elsewhere in the body. The score helps decide whether chemotherapy is likely to add benefit on top of hormone treatment.

Rates data updated October 2026.

How much does Breast Cancer Gene Activity Recurrence Score cost?

$3,162

Typical negotiated rate. In South Carolina, October 2026.

Insurers have agreed to pay about $3,162 for this service. The price depends on where it is billed: about $3,162 from a physician practice, and about $8,128 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$3,162$2,692 to $3,890
FacilityA hospital or hospital-owned outpatient department$8,128$4,074 to $17,783

How much rates vary

Facilitymedian $8,128 · 10th to 90th $3,020 to $23,988Professionalmedian $3,162 · 10th to 90th $1,820 to $4,677
$2K$5K$10K$20Kfacility $8,128professional $3,162

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$3,019.95
Median
$3,019.95
Typical High
$3,019.95
Aetna
Setting
Professional
Modifier
None
Typical Low
$3,019.95
Median
$3,019.95
Typical High
$3,090.30
BCBS South Carolina
Setting
Facility
Modifier
None
Typical Low
$20,892.96
Median
$20,892.96
Typical High
$21,379.62
BCBS South Carolina
Setting
Professional
Modifier
None
Typical Low
$3,162.28
Median
$3,801.89
Typical High
$4,786.30
Cigna
Setting
Facility
Modifier
None
Typical Low
$7,244.36
Median
$9,772.37
Typical High
$23,988.33
Cigna
Setting
Professional
Modifier
None
Typical Low
$1,737.80
Median
$1,819.70
Typical High
$4,677.35
Medcost
Setting
Facility
Modifier
None
Typical Low
$3,019.95
Median
$3,630.78
Typical High
$11,220.18
Medcost
Setting
Professional
Modifier
None
Typical Low
$3,890.45
Median
$3,890.45
Typical High
$5,370.32
United
Setting
Facility
Modifier
None
Typical Low
$3,467.37
Median
$3,467.37
Typical High
$4,677.35
United
Setting
Professional
Modifier
None
Typical Low
$1,621.81
Median
$2,344.23
Typical High
$3,890.45
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$1,513.56
Median
$1,513.56
Typical High
$1,548.82
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$602.56
Median
$602.56
Typical High
$616.60
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$1,949.84
Median
$1,949.84
Typical High
$3,090.30

Where South Carolina sits

The same service costs 5.4 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 36th of 51

$3,162

AK $8,710AL $1,622

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.