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Breast Cancer Gene Activity Recurrence Score

Mississippi rates for HCPCS 81521

A laboratory test on a sample of breast cancer tissue that measures the activity of a panel of genes and combines the results into a score estimating how likely the cancer is to come back elsewhere in the body. The score helps decide whether chemotherapy is likely to add benefit on top of hormone treatment.

Rates data updated October 2026.

How much does Breast Cancer Gene Activity Recurrence Score cost?

$3,981

Typical negotiated rate. In Mississippi, October 2026.

Insurers have agreed to pay about $3,981 for this service. The price depends on where it is billed: about $3,981 from a physician practice, and about $3,981 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 4 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$3,981$2,138 to $5,754
FacilityA hospital or hospital-owned outpatient department$3,981$3,981 to $3,981

How much rates vary

Facilitymedian $3,981 · 10th to 90th $3,467 to $6,918Professionalmedian $3,981 · 10th to 90th $1,778 to $6,918
$2K$5K$10Kfacility $3,981professional $3,981

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$4,168.69
Median
$6,918.31
Typical High
$7,943.28
Aetna
Setting
Professional
Modifier
None
Typical Low
$4,168.69
Median
$6,918.31
Typical High
$7,943.28
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$2,089.30
Median
$3,467.37
Typical High
$3,890.45
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$831.76
Median
$1,380.38
Typical High
$1,584.89
BCBS Mississippi
Setting
Facility
Modifier
None
Typical Low
$3,981.07
Median
$3,981.07
Typical High
$3,981.07
BCBS Mississippi
Setting
Professional
Modifier
None
Typical Low
$3,981.07
Median
$3,981.07
Typical High
$3,981.07
Cigna
Setting
Facility
Modifier
None
Typical Low
$2,511.89
Median
$2,630.27
Typical High
$3,235.94
Cigna
Setting
Professional
Modifier
None
Typical Low
$1,659.59
Median
$3,019.95
Typical High
$6,456.54
United
Setting
Facility
Modifier
None
Typical Low
$3,467.37
Median
$3,467.37
Typical High
$4,677.35
United
Setting
Professional
Modifier
None
Typical Low
$1,621.81
Median
$2,137.96
Typical High
$8,709.64

Where Mississippi sits

The same service costs 5.4 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Mississippi· 18th of 51

$3,981

AK $8,710AL $1,622

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.