go back

Highly Complex Genetic Laboratory Analysis

Massachusetts rates for HCPCS 81407

This represents one of the most technically complex levels of gene-based laboratory analysis available, used when evaluating certain inherited conditions or cancer-related genetic changes that require especially involved laboratory work to identify. The complexity reflects factors such as the size of the genetic region examined and the analytic methods required, rather than testing for one single, simple genetic change. It requires only a blood or tissue sample.

Rates data updated October 2026.

How much does Highly Complex Genetic Laboratory Analysis cost?

$1,202

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $1,202 for this service. The price depends on where it is billed: about $1,122 from a physician practice, and about $1,479 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$1,122$513 to $2,138
FacilityA hospital or hospital-owned outpatient department$1,479$1,122 to $2,089

How much rates vary

Facilitymedian $1,479 · 10th to 90th $851 to $2,692Professionalmedian $1,122 · 10th to 90th $513 to $4,266
$100$200$500$1K$2K$5Kfacility $1,479professional $1,122

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$1,202.26
Median
$1,202.26
Typical High
$1,202.26
Aetna
Setting
Professional
Modifier
None
Typical Low
$1,202.26
Median
$1,202.26
Typical High
$1,202.26
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$933.25
Median
$1,778.28
Typical High
$2,754.23
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$512.86
Median
$1,621.81
Typical High
$4,265.80
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$1,348.96
Median
$1,905.46
Typical High
$2,691.53
BCBS Massachusetts
Setting
Professional
Modifier
None
Typical Low
$363.08
Median
$363.08
Typical High
$831.76
Cigna
Setting
Facility
Modifier
None
Typical Low
$537.03
Median
$933.25
Typical High
$1,659.59
Cigna
Setting
Professional
Modifier
None
Typical Low
$501.19
Median
$891.25
Typical High
$3,311.31
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$1,412.54
Typical High
$5,888.44
Fallon Health
Setting
Professional
Modifier
None
Typical Low
$1,202.26
Median
$1,202.26
Typical High
$1,412.54
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$512.86
Median
$851.14
Typical High
$1,905.46
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$933.25
Median
$1,778.28
Typical High
$2,754.23
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$512.86
Median
$1,621.81
Typical High
$4,265.80
United
Setting
Facility
Modifier
None
Typical Low
$758.58
Median
$851.14
Typical High
$1,023.29
United
Setting
Professional
Modifier
None
Typical Low
$338.84
Median
$512.86
Typical High
$1,621.81
Well Sense
Setting
Facility
Modifier
None
Typical Low
$741.31
Median
$1,023.29
Typical High
$1,548.82
Well Sense
Setting
Professional
Modifier
None
Typical Low
$2,511.89
Median
$2,511.89
Typical High
$3,019.95
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$602.56
Median
$602.56
Typical High
$602.56
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$239.88
Median
$239.88
Typical High
$239.88
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$851.14
Median
$1,096.48
Typical High
$1,318.26

Where Massachusetts sits

The same service costs 4.4 times more in Alaska than in Oklahoma. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 5th of 51

$1,202

AK $1,905OK $437

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.