go back

Targeted Gene Sequencing Analysis

Massachusetts rates for HCPCS 81405

This laboratory analysis examines the DNA sequence of a specific gene associated with an inherited condition, looking for changes that could explain a patient's symptoms or family history. It is one of many single-gene analyzes available, each ordered based on the particular condition being evaluated. Results help confirm a diagnosis or guide further testing and family counseling.

Rates data updated October 2026.

How much does Targeted Gene Sequencing Analysis cost?

$316

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $316 for this service. The price depends on where it is billed: about $302 from a physician practice, and about $525 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$302$182 to $759
FacilityA hospital or hospital-owned outpatient department$525$398 to $832

How much rates vary

Facilitymedian $525 · 10th to 90th $302 to $1,047Professionalmedian $302 · 10th to 90th $174 to $1,514
$100$200$500$1K$2K$5Kfacility $525professional $302

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$173.78
Aetna
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$173.78
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$831.76
Typical High
$1,047.13
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$181.97
Median
$575.44
Typical High
$1,513.56
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$478.63
Median
$676.08
Typical High
$954.99
BCBS Massachusetts
Setting
Professional
Modifier
None
Typical Low
$77.62
Median
$77.62
Typical High
$77.62
Cigna
Setting
Facility
Modifier
None
Typical Low
$194.98
Median
$371.54
Typical High
$588.84
Cigna
Setting
Professional
Modifier
None
Typical Low
$181.97
Median
$316.23
Typical High
$1,174.90
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$512.86
Typical High
$5,888.44
Fallon Health
Setting
Professional
Modifier
None
Typical Low
$426.58
Median
$426.58
Typical High
$512.86
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$181.97
Median
$302.00
Typical High
$676.08
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$831.76
Typical High
$1,047.13
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$181.97
Median
$575.44
Typical High
$1,513.56
United
Setting
Facility
Modifier
None
Typical Low
$269.15
Median
$302.00
Typical High
$363.08
United
Setting
Professional
Modifier
None
Typical Low
$120.23
Median
$181.97
Typical High
$575.44
Well Sense
Setting
Facility
Modifier
None
Typical Low
$263.03
Median
$371.54
Typical High
$549.54
Well Sense
Setting
Professional
Modifier
None
Typical Low
$2,511.89
Median
$2,511.89
Typical High
$3,019.95
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$87.10
Median
$87.10
Typical High
$87.10
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$34.67
Median
$34.67
Typical High
$34.67
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$302.00
Median
$389.05
Typical High
$467.74

Where Massachusetts sits

The same service costs 3.9 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 17th of 51

$316

AK $676AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.