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High-Resolution Tissue-Type Test, Single Marker

North Carolina rates for HCPCS 81381

This is a detailed genetic test that examines one specific immune-system marker gene at high resolution, most often used before a bone marrow, stem cell, or organ transplant to see how closely a donor's tissue type matches the recipient's. Fine-grained matching on these markers helps predict how well a transplant will be tolerated. The test is run on a blood sample.

Rates data updated October 2026.

How much does High-Resolution Tissue-Type Test, Single Marker cost?

$110

Typical negotiated rate. In North Carolina, October 2026.

Insurers have agreed to pay about $110 for this service. The price depends on where it is billed: about $110 from a physician practice, and about $363 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$110$58.88 to $158
FacilityA hospital or hospital-owned outpatient department$363$135 to $447

How much rates vary

Facilitymedian $363 · 10th to 90th $135 to $776Professionalmedian $110 · 10th to 90th $59 to $245
$100$200$500$1Kfacility $363professional $110

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$134.90
Typical High
$213.80
Aetna
Setting
Professional
Modifier
None
Typical Low
$131.83
Median
$134.90
Typical High
$213.80
BCBS North Carolina
Setting
Facility
Modifier
None
Typical Low
$338.84
Median
$389.05
Typical High
$398.11
BCBS North Carolina
Setting
Professional
Modifier
None
Typical Low
$58.88
Median
$109.65
Typical High
$245.47
Cigna
Setting
Facility
Modifier
None
Typical Low
$128.82
Median
$371.54
Typical High
$776.25
Cigna
Setting
Professional
Modifier
None
Typical Low
$79.43
Median
$120.23
Typical High
$229.09
Medcost
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$134.90
Typical High
$204.17
Medcost
Setting
Professional
Modifier
None
Typical Low
$128.82
Median
$128.82
Typical High
$295.12
United
Setting
Professional
Modifier
None
Typical Low
$64.57
Median
$102.33
Typical High
$169.82
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$66.07
Median
$67.61
Typical High
$102.33
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$26.30
Median
$26.92
Typical High
$40.74
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$64.57
Median
$64.57
Typical High
$234.42

Where North Carolina sits

The same service costs 3.5 times more in Alaska than in North Carolina. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 51st of 51

$110

AK $380NC $110

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.