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High-Resolution Tissue-Type Test, Single Marker

Illinois rates for HCPCS 81381

This is a detailed genetic test that examines one specific immune-system marker gene at high resolution, most often used before a bone marrow, stem cell, or organ transplant to see how closely a donor's tissue type matches the recipient's. Fine-grained matching on these markers helps predict how well a transplant will be tolerated. The test is run on a blood sample.

Rates data updated October 2026.

How much does High-Resolution Tissue-Type Test, Single Marker cost?

$132

Typical negotiated rate. In Illinois, October 2026.

Insurers have agreed to pay about $132 for this service. The price depends on where it is billed: about $117 from a physician practice, and about $316 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$117$3.98 to $132
FacilityA hospital or hospital-owned outpatient department$316$209 to $603

How much rates vary

Facilitymedian $316 · 10th to 90th $178 to $1,072Professionalmedian $117 · 10th to 90th $3 to $200
$5$20$100$500$2Kfacility $316professional $117

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$138.04
Median
$263.03
Typical High
$512.86
Aetna
Setting
Professional
Modifier
None
Typical Low
$102.33
Median
$138.04
Typical High
$151.36
BCBS Illinois
Setting
Facility
Modifier
None
Typical Low
$204.17
Median
$295.12
Typical High
$2,137.96
BCBS Illinois
Setting
Professional
Modifier
None
Typical Low
$3.47
Median
$117.49
Typical High
$131.83
Cigna
Setting
Facility
Modifier
None
Typical Low
$190.55
Median
$354.81
Typical High
$707.95
Cigna
Setting
Professional
Modifier
None
Typical Low
$85.11
Median
$194.98
Typical High
$281.84
Hally Health
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$257.04
Typical High
$446.68
Hally Health
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
None
Typical Low
$218.78
Median
$218.78
Typical High
$218.78
United
Setting
Facility
Modifier
None
Typical Low
$169.82
Median
$204.17
Typical High
$213.80
United
Setting
Professional
Modifier
None
Typical Low
$70.79
Median
$102.33
Typical High
$169.82
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$69.18
Median
$123.03
Typical High
$257.04
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$27.54
Median
$48.98
Typical High
$102.33
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$69.18
Median
$69.18
Typical High
$75.86
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$27.54
Median
$27.54
Typical High
$30.90

Where Illinois sits

The same service costs 3.5 times more in Alaska than in North Carolina. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Illinois· 44th of 51

$132

AK $380NC $110

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.