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High-Resolution Tissue-Type Test, Single Marker

Colorado rates for HCPCS 81381

This is a detailed genetic test that examines one specific immune-system marker gene at high resolution, most often used before a bone marrow, stem cell, or organ transplant to see how closely a donor's tissue type matches the recipient's. Fine-grained matching on these markers helps predict how well a transplant will be tolerated. The test is run on a blood sample.

Rates data updated October 2026.

How much does High-Resolution Tissue-Type Test, Single Marker cost?

$224

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $224 for this service. The price depends on where it is billed: about $102 from a physician practice, and about $490 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$102$70.79 to $219
FacilityA hospital or hospital-owned outpatient department$490$316 to $589

How much rates vary

Facilitymedian $490 · 10th to 90th $132 to $776Professionalmedian $102 · 10th to 90th $71 to $347
$100$200$500$1Kfacility $490professional $102

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$128.82
Median
$354.81
Typical High
$776.25
Aetna
Setting
Professional
Modifier
None
Typical Low
$128.82
Median
$128.82
Typical High
$234.42
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$177.83
Median
$512.86
Typical High
$776.25
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$70.79
Median
$70.79
Typical High
$371.54
Cigna
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$204.17
Typical High
$537.03
Cigna
Setting
Professional
Modifier
None
Typical Low
$79.43
Median
$89.13
Typical High
$245.47
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$128.82
Median
$151.36
Typical High
$186.21
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$169.82
Median
$239.88
Typical High
$436.52
Select Health
Setting
Facility
Modifier
None
Typical Low
$169.82
Median
$316.23
Typical High
$354.81
Select Health
Setting
Professional
Modifier
None
Typical Low
$120.23
Median
$169.82
Typical High
$257.04
United
Setting
Facility
Modifier
None
Typical Low
$204.17
Median
$204.17
Typical High
$204.17
United
Setting
Professional
Modifier
None
Typical Low
$53.70
Median
$70.79
Typical High
$125.89
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$63.10
Median
$64.57
Typical High
$89.13
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$25.70
Median
$25.70
Typical High
$36.31

Where Colorado sits

The same service costs 3.5 times more in Alaska than in North Carolina. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 7th of 51

$224

AK $380NC $110

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.