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TP53 Gene Test For A Known Family Change

South Carolina rates for HCPCS 81353

Checks a blood or saliva sample for one particular change in the TP53 gene that has already been found in a relative. TP53 normally helps stop cells from growing out of control, and inherited changes in it raise the risk of several cancers, sometimes at a young age. Because the exact change being looked for is already known, only that one spot is examined.

Rates data updated October 2026.

How much does TP53 Gene Test For A Known Family Change cost?

$240

Typical negotiated rate. In South Carolina, October 2026.

Insurers have agreed to pay about $240 for this service. The price depends on where it is billed: about $214 from a physician practice, and about $631 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$214$129 to $309
FacilityA hospital or hospital-owned outpatient department$631$324 to $1,175

How much rates vary

Facilitymedian $631 · 10th to 90th $240 to $1,905Professionalmedian $214 · 10th to 90th $129 to $309
$100$200$500$1Kfacility $631professional $214

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$239.88
Median
$239.88
Typical High
$239.88
Aetna
Setting
Professional
Modifier
None
Typical Low
$239.88
Median
$239.88
Typical High
$245.47
BCBS South Carolina
Setting
Professional
Modifier
None
Typical Low
$128.82
Median
$169.82
Typical High
$309.03
Cigna
Setting
Facility
Modifier
None
Typical Low
$588.84
Median
$776.25
Typical High
$1,905.46
Cigna
Setting
Professional
Modifier
None
Typical Low
$141.25
Median
$147.91
Typical High
$371.54
Medcost
Setting
Facility
Modifier
None
Typical Low
$239.88
Median
$288.40
Typical High
$891.25
Medcost
Setting
Professional
Modifier
None
Typical Low
$245.47
Median
$245.47
Typical High
$426.58
United
Setting
Facility
Modifier
None
Typical Low
$275.42
Median
$275.42
Typical High
$371.54
United
Setting
Professional
Modifier
None
Typical Low
$128.82
Median
$186.21
Typical High
$309.03
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$120.23
Median
$120.23
Typical High
$123.03
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$47.86
Median
$47.86
Typical High
$48.98
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$123.03
Median
$123.03
Typical High
$245.47

Where South Carolina sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 42nd of 51

$240

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.