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TP53 Gene Test For A Known Family Change

North Carolina rates for HCPCS 81353

Checks a blood or saliva sample for one particular change in the TP53 gene that has already been found in a relative. TP53 normally helps stop cells from growing out of control, and inherited changes in it raise the risk of several cancers, sometimes at a young age. Because the exact change being looked for is already known, only that one spot is examined.

Rates data updated October 2026.

How much does TP53 Gene Test For A Known Family Change cost?

$295

Typical negotiated rate. In North Carolina, October 2026.

Insurers have agreed to pay about $295 for this service. The price depends on where it is billed: about $275 from a physician practice, and about $661 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$275$245 to $468
FacilityA hospital or hospital-owned outpatient department$661$245 to $1,413

How much rates vary

Facilitymedian $661 · 10th to 90th $245 to $1,413Professionalmedian $275 · 10th to 90th $155 to $813
$200$500$1Kfacility $661professional $275

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$245.47
Median
$245.47
Typical High
$245.47
Aetna
Setting
Professional
Modifier
None
Typical Low
$239.88
Median
$245.47
Typical High
$295.12
BCBS North Carolina
Setting
Facility
Modifier
None
Typical Low
$676.08
Median
$691.83
Typical High
$977.24
BCBS North Carolina
Setting
Professional
Modifier
None
Typical Low
$263.03
Median
$338.84
Typical High
$977.24
Cigna
Setting
Facility
Modifier
None
Typical Low
$257.04
Median
$812.83
Typical High
$1,412.54
Cigna
Setting
Professional
Modifier
None
Typical Low
$144.54
Median
$229.09
Typical High
$489.78
Medcost
Setting
Facility
Modifier
None
Typical Low
$245.47
Median
$245.47
Typical High
$363.08
Medcost
Setting
Professional
Modifier
None
Typical Low
$245.47
Median
$245.47
Typical High
$524.81
United
Setting
Professional
Modifier
None
Typical Low
$128.82
Median
$186.21
Typical High
$316.23
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$120.23
Median
$123.03
Typical High
$144.54
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$47.86
Median
$48.98
Typical High
$58.88
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$123.03
Median
$123.03
Typical High
$398.11

Where North Carolina sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 28th of 51

$295

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.