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TP53 Gene Test For A Known Family Change

Colorado rates for HCPCS 81353

Checks a blood or saliva sample for one particular change in the TP53 gene that has already been found in a relative. TP53 normally helps stop cells from growing out of control, and inherited changes in it raise the risk of several cancers, sometimes at a young age. Because the exact change being looked for is already known, only that one spot is examined.

Rates data updated October 2026.

How much does TP53 Gene Test For A Known Family Change cost?

$407

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $407 for this service. The price depends on where it is billed: about $186 from a physician practice, and about $891 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$186$129 to $398
FacilityA hospital or hospital-owned outpatient department$891$575 to $1,072

How much rates vary

Facilitymedian $891 · 10th to 90th $240 to $1,413Professionalmedian $186 · 10th to 90th $129 to $631
$200$500$1K$2Kfacility $891professional $186

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$645.65
Typical High
$1,412.54
Aetna
Setting
Professional
Modifier
None
Typical Low
$229.09
Median
$234.42
Typical High
$323.59
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$323.59
Median
$933.25
Typical High
$1,412.54
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$128.82
Median
$128.82
Typical High
$676.08
Cigna
Setting
Facility
Modifier
None
Typical Low
$181.97
Median
$269.15
Typical High
$977.24
Cigna
Setting
Professional
Modifier
None
Typical Low
$141.25
Median
$162.18
Typical High
$446.68
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$234.42
Median
$275.42
Typical High
$407.38
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$309.03
Median
$436.52
Typical High
$676.08
Select Health
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$575.44
Typical High
$645.65
Select Health
Setting
Professional
Modifier
None
Typical Low
$213.80
Median
$309.03
Typical High
$457.09
United
Setting
Facility
Modifier
None
Typical Low
$371.54
Median
$371.54
Typical High
$371.54
United
Setting
Professional
Modifier
None
Typical Low
$128.82
Median
$128.82
Typical High
$229.09
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$114.82
Median
$117.49
Typical High
$162.18
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$45.71
Median
$46.77
Typical High
$64.57

Where Colorado sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 5th of 51

$407

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.