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Genetic Test for Changes in a Single Gene

Missouri rates for HCPCS 81351

A laboratory test that examines DNA from a blood or tissue sample to look for changes in one specific gene. The result is used to help confirm a diagnosis, assess risk, or guide treatment decisions, and is normally interpreted alongside personal and family medical history.

Rates data updated July 2026.

How much does Genetic Test for Changes in a Single Gene cost?

$646

Typical negotiated rate. In Missouri, July 2026.

Insurers have agreed to pay about $646 for this service. The price depends on where it is billed: about $562 from a physician practice, and about $832 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$562$309 to $759
FacilityA hospital or hospital-owned outpatient department$832$646 to $1,122

How much rates vary

Facilitymedian $832 · 10th to 90th $617 to $1,479Professionalmedian $562 · 10th to 90th $257 to $1,230
$500$1K$2Kfacility $832professional $562

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$616.60
Median
$1,071.52
Typical High
$1,479.11
Aetna
Setting
Professional
Modifier
Global
Typical Low
$549.54
Median
$562.34
Typical High
$1,288.25
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$645.65
Median
$645.65
Typical High
$2,238.72
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$257.04
Median
$263.03
Typical High
$1,148.15
BCBS
Setting
Facility
Modifier
Global
Typical Low
$891.25
Median
$954.99
Typical High
$1,659.59
BCBS
Setting
Professional
Modifier
Global
Typical Low
$446.68
Median
$645.65
Typical High
$1,096.48
Cigna
Setting
Facility
Modifier
Global
Typical Low
$912.01
Median
$1,348.96
Typical High
$3,311.31
Cigna
Setting
Professional
Modifier
Global
Typical Low
$281.84
Median
$338.84
Typical High
$891.25
Medica
Setting
Facility
Modifier
Global
Typical Low
$549.54
Median
$776.25
Typical High
$3,019.95
Medica
Setting
Professional
Modifier
Global
Typical Low
$269.15
Median
$389.05
Typical High
$3,162.28
United
Setting
Facility
Modifier
Global
Typical Low
$269.15
Median
$645.65
Typical High
$776.25
United
Setting
Professional
Modifier
Global
Typical Low
$269.15
Median
$389.05
Typical High
$870.96

Where Missouri sits

The same service costs 3.4 times more in Alaska than in Delaware. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 28th of 51

$646

AK $1,445DE $427

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.