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Genetic Test for Changes in a Single Gene

Florida rates for HCPCS 81351

A laboratory test that examines DNA from a blood or tissue sample to look for changes in one specific gene. The result is used to help confirm a diagnosis, assess risk, or guide treatment decisions, and is normally interpreted alongside personal and family medical history.

Rates data updated July 2026.

How much does Genetic Test for Changes in a Single Gene cost?

$457

Typical negotiated rate. In Florida, July 2026.

Insurers have agreed to pay about $457 for this service. The price depends on where it is billed: about $447 from a physician practice, and about $1,047 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$447$389 to $525
FacilityA hospital or hospital-owned outpatient department$1,047$550 to $1,738

How much rates vary

Facilitymedian $1,047 · 10th to 90th $457 to $3,467Professionalmedian $447 · 10th to 90th $339 to $646
$10$50$200$1Kfacility $1,047professional $447

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$457.09
Median
$1,047.13
Typical High
$3,467.37
Aetna
Setting
Professional
Modifier
Global
Typical Low
$389.05
Median
$446.68
Typical High
$575.44
AvMed
Setting
Facility
Modifier
Global
Typical Low
$562.34
Median
$645.65
Typical High
$758.58
AvMed
Setting
Professional
Modifier
Global
Typical Low
$436.52
Median
$645.65
Typical High
$645.65
Cigna
Setting
Facility
Modifier
Global
Typical Low
$331.13
Median
$489.78
Typical High
$2,630.27
Cigna
Setting
Professional
Modifier
Global
Typical Low
$316.23
Median
$467.74
Typical High
$1,122.02
Florida Blue
Setting
Facility
Modifier
Global
Typical Low
$1,174.90
Median
$1,174.90
Typical High
$1,174.90
Florida Blue
Setting
Professional
Modifier
Global
Typical Low
$389.05
Median
$389.05
Typical High
$549.54
Molina
Setting
Professional
Modifier
Global
Typical Low
$389.05
Median
$524.81
Typical High
$645.65
United
Setting
Facility
Modifier
Global
Typical Low
$269.15
Median
$575.44
Typical High
$645.65
United
Setting
Professional
Modifier
Global
Typical Low
$223.87
Median
$269.15
Typical High
$851.14
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$389.05
Median
$645.65
Typical High
$645.65

Where Florida sits

The same service costs 3.4 times more in Alaska than in Delaware. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Florida· 50th of 51

$457

AK $1,445DE $427

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.