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Genetic Test for Changes in a Single Gene

Colorado rates for HCPCS 81351

A laboratory test that examines DNA from a blood or tissue sample to look for changes in one specific gene. The result is used to help confirm a diagnosis, assess risk, or guide treatment decisions, and is normally interpreted alongside personal and family medical history.

Rates data updated July 2026.

How much does Genetic Test for Changes in a Single Gene cost?

$676

Typical negotiated rate. In Colorado, July 2026.

Insurers have agreed to pay about $676 for this service. The price depends on where it is billed: about $490 from a physician practice, and about $1,549 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$490$389 to $525
FacilityA hospital or hospital-owned outpatient department$1,549$851 to $2,692

How much rates vary

Facilitymedian $1,549 · 10th to 90th $490 to $3,236Professionalmedian $490 · 10th to 90th $269 to $692
$500$1K$2K$5Kfacility $1,549professional $490

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$407.38
Median
$1,348.96
Typical High
$3,019.95
Aetna
Setting
Professional
Modifier
Global
Typical Low
$407.38
Median
$489.78
Typical High
$691.83
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$794.33
Median
$1,905.46
Typical High
$3,235.94
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$257.04
Median
$269.15
Typical High
$645.65
Cigna
Setting
Facility
Modifier
Global
Typical Low
$338.84
Median
$416.87
Typical High
$1,949.84
Cigna
Setting
Professional
Modifier
Global
Typical Low
$295.12
Median
$346.74
Typical High
$933.25
Denver HMP
Setting
Facility
Modifier
Global
Typical Low
$489.78
Median
$645.65
Typical High
$977.24
Kaiser Permanente
Setting
Professional
Modifier
Global
Typical Low
$891.25
Median
$912.01
Typical High
$1,202.26
Select Health
Setting
Facility
Modifier
Global
Typical Low
$676.08
Median
$1,174.90
Typical High
$1,348.96
Select Health
Setting
Professional
Modifier
Global
Typical Low
$446.68
Median
$645.65
Typical High
$954.99
United
Setting
Facility
Modifier
Global
Typical Low
$575.44
Median
$645.65
Typical High
$954.99
United
Setting
Professional
Modifier
Global
Typical Low
$269.15
Median
$269.15
Typical High
$478.63

Where Colorado sits

The same service costs 3.4 times more in Alaska than in Delaware. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 14th of 51

$676

AK $1,445DE $427

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.