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Genetic Test For Thiopurine Drug Handling

South Dakota rates for HCPCS 81335

A blood or saliva test that looks for common inherited changes in a gene controlling how the body breaks down a group of medicines used for leukemia, inflammatory bowel disease, and some autoimmune conditions. People carrying these changes clear the drug slowly and can develop dangerously low blood counts on a standard dose. The result is used to set a safe starting dose or to choose a different medicine.

Rates data updated July 2026.

How much does Genetic Test For Thiopurine Drug Handling cost?

$263

Typical negotiated rate. In South Dakota, July 2026.

Insurers have agreed to pay about $263 for this service. The price depends on where it is billed: about $229 from a physician practice, and about $331 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$229$135 to $407
FacilityA hospital or hospital-owned outpatient department$331$263 to $331

How much rates vary

Facilitymedian $331 · 10th to 90th $178 to $331Professionalmedian $229 · 10th to 90th $117 to $417
$100$200$500facility $331professional $229

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$123.03
Median
$199.53
Typical High
$199.53
Aetna
Setting
Professional
Modifier
Global
Typical Low
$117.49
Median
$134.90
Typical High
$165.96
Avera
Setting
Facility
Modifier
Global
Typical Low
$177.83
Median
$177.83
Typical High
$263.03
Avera
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$173.78
Typical High
$173.78
Cigna
Setting
Facility
Modifier
Global
Typical Low
$331.13
Median
$331.13
Typical High
$331.13
Cigna
Setting
Professional
Modifier
Global
Typical Low
$208.93
Median
$331.13
Typical High
$416.87
Medica
Setting
Facility
Modifier
Global
Typical Low
$165.96
Median
$199.53
Typical High
$323.59
Medica
Setting
Professional
Modifier
Global
Typical Low
$89.13
Median
$89.13
Typical High
$870.96
Sanford Health Plan
Setting
Professional
Modifier
Global
Typical Low
$251.19
Median
$407.38
Typical High
$478.63
United
Setting
Professional
Modifier
Global
Typical Low
$74.13
Median
$104.71
Typical High
$229.09
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$173.78
Typical High
$173.78

Where South Dakota sits

The same service costs 3.3 times more in Alaska than in Delaware. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 3rd of 51

$263

AK $389DE $117

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.