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Genetic Test For Thiopurine Drug Handling

Pennsylvania rates for HCPCS 81335

A blood or saliva test that looks for common inherited changes in a gene controlling how the body breaks down a group of medicines used for leukemia, inflammatory bowel disease, and some autoimmune conditions. People carrying these changes clear the drug slowly and can develop dangerously low blood counts on a standard dose. The result is used to set a safe starting dose or to choose a different medicine.

Rates data updated July 2026.

How much does Genetic Test For Thiopurine Drug Handling cost?

$162

Typical negotiated rate. In Pennsylvania, July 2026.

Insurers have agreed to pay about $162 for this service. The price depends on where it is billed: about $141 from a physician practice, and about $363 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$141$115 to $166
FacilityA hospital or hospital-owned outpatient department$363$224 to $525

How much rates vary

Facilitymedian $363 · 10th to 90th $148 to $776Professionalmedian $141 · 10th to 90th $95 to $363
$100$200$500$1Kfacility $363professional $141

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$147.91
Median
$338.84
Typical High
$616.60
Aetna
Setting
Professional
Modifier
Global
Typical Low
$95.50
Median
$141.25
Typical High
$616.60
Capital Blue Cross
Setting
Facility
Modifier
Global
Typical Low
$630.96
Median
$851.14
Typical High
$8,511.38
Capital Blue Cross
Setting
Professional
Modifier
Global
Typical Low
$134.90
Median
$134.90
Typical High
$134.90
Cigna
Setting
Facility
Modifier
Global
Typical Low
$169.82
Median
$288.40
Typical High
$602.56
Cigna
Setting
Professional
Modifier
Global
Typical Low
$81.28
Median
$147.91
Typical High
$302.00
Emblem Health
Setting
Professional
Modifier
Global
Typical Low
$123.03
Median
$123.03
Typical High
$229.09
Geisinger
Setting
Facility
Modifier
Global
Typical Low
$173.78
Median
$173.78
Typical High
$173.78
Geisinger
Setting
Professional
Modifier
Global
Typical Low
$131.83
Median
$199.53
Typical High
$331.13
Highmark BCBS
Setting
Facility
Modifier
Global
Typical Low
$309.03
Median
$363.08
Typical High
$831.76
Martin's Point
Setting
Facility
Modifier
Global
Typical Low
$141.25
Median
$338.84
Typical High
$616.60
Martin's Point
Setting
Professional
Modifier
Global
Typical Low
$95.50
Median
$144.54
Typical High
$616.60
UPMC Health Plan
Setting
Facility
Modifier
Global
Typical Low
$436.52
Median
$794.33
Typical High
$1,412.54
UPMC Health Plan
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$173.78
Typical High
$190.55
United
Setting
Facility
Modifier
Global
Typical Low
$158.49
Median
$173.78
Typical High
$208.93
United
Setting
Professional
Modifier
Global
Typical Low
$74.13
Median
$104.71
Typical High
$245.47

Where Pennsylvania sits

The same service costs 3.3 times more in Alaska than in Delaware. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Pennsylvania· 34th of 51

$162

AK $389DE $117

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.