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Targeted Single-Gene Variant Test

South Carolina rates for HCPCS 81333

A laboratory test that examines one specific gene in a blood or tissue sample and reports whether a defined set of known changes is present. Testing of this kind is ordered when a particular genetic change is suspected, either to confirm a diagnosis or to find out whether someone carries the change.

Rates data updated July 2026.

How much does Targeted Single-Gene Variant Test cost?

$110

Typical negotiated rate. In South Carolina, July 2026.

Insurers have agreed to pay about $110 for this service. The price depends on where it is billed: about $107 from a physician practice, and about $339 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$107$107 to $112
FacilityA hospital or hospital-owned outpatient department$339$117 to $437

How much rates vary

Facilitymedian $339 · 10th to 90th $107 to $646Professionalmedian $107 · 10th to 90th $81 to $145
$100$200$500facility $339professional $107

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$107.15
Median
$338.84
Typical High
$645.65
Aetna
Setting
Professional
Modifier
Global
Typical Low
$107.15
Median
$107.15
Typical High
$123.03
BCBS
Setting
Facility
Modifier
Global
Typical Low
$851.14
Median
$851.14
Typical High
$891.25
BCBS
Setting
Professional
Modifier
Global
Typical Low
$89.13
Median
$134.90
Typical High
$186.21
Cigna
Setting
Facility
Modifier
Global
Typical Low
$257.04
Median
$446.68
Typical High
$776.25
Cigna
Setting
Professional
Modifier
Global
Typical Low
$61.66
Median
$64.57
Typical High
$181.97
Medcost
Setting
Facility
Modifier
Global
Typical Low
$107.15
Median
$123.03
Typical High
$181.97
United
Setting
Facility
Modifier
Global
Typical Low
$123.03
Median
$138.04
Typical High
$165.96
United
Setting
Professional
Modifier
Global
Typical Low
$57.54
Median
$81.28
Typical High
$138.04

Where South Carolina sits

The same service costs 3.4 times more in Alaska than in Delaware. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 44th of 51

$110

AK $309DE $91.20

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.