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Targeted Single-Gene Variant Test

Iowa rates for HCPCS 81333

A laboratory test that examines one specific gene in a blood or tissue sample and reports whether a defined set of known changes is present. Testing of this kind is ordered when a particular genetic change is suspected, either to confirm a diagnosis or to find out whether someone carries the change.

Rates data updated July 2026.

How much does Targeted Single-Gene Variant Test cost?

$138

Typical negotiated rate. In Iowa, July 2026.

Insurers have agreed to pay about $138 for this service. The price depends on where it is billed: about $120 from a physician practice, and about $209 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$120$105 to $263
FacilityA hospital or hospital-owned outpatient department$209$138 to $363

How much rates vary

Facilitymedian $209 · 10th to 90th $105 to $398Professionalmedian $120 · 10th to 90th $81 to $912
$100$200$500$1Kfacility $209professional $120

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$104.71
Median
$281.84
Typical High
$398.11
Aetna
Setting
Professional
Modifier
Global
Typical Low
$91.20
Median
$120.23
Typical High
$912.01
Cigna
Setting
Professional
Modifier
Global
Typical Low
$177.83
Median
$263.03
Typical High
$331.13
Hally Health
Setting
Professional
Modifier
Global
Typical Low
$151.36
Median
$245.47
Typical High
$380.19
Medica
Setting
Facility
Modifier
Global
Typical Low
$138.04
Median
$165.96
Typical High
$363.08
Medica
Setting
Professional
Modifier
Global
Typical Low
$81.28
Median
$141.25
Typical High
$549.54
Midlands
Setting
Professional
Modifier
Global
Typical Low
$169.82
Median
$181.97
Typical High
$181.97
Oscar Health
Setting
Professional
Modifier
Global
Typical Low
$138.04
Median
$147.91
Typical High
$295.12
United
Setting
Facility
Modifier
Global
Typical Low
$138.04
Median
$138.04
Typical High
$302.00
United
Setting
Professional
Modifier
Global
Typical Low
$81.28
Median
$81.28
Typical High
$346.74
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$138.04
Median
$138.04
Typical High
$138.04

Where Iowa sits

The same service costs 3.4 times more in Alaska than in Delaware. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Iowa· 23rd of 51

$138

AK $309DE $91.20

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.