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Prader-Willi/Angelman Genetic Test

North Carolina rates for HCPCS 81331

This service is a genetic laboratory test that looks at a specific pattern of gene activity to help diagnose Prader-Willi syndrome or Angelman syndrome, two different inherited conditions that affect development. It is typically ordered when a child shows developmental delay, low muscle tone, feeding difficulties, or other features suggestive of one of these conditions. The test is run on a blood sample.

Rates data updated October 2026.

How much does Prader-Willi/Angelman Genetic Test cost?

$51.29

Typical negotiated rate. In North Carolina, October 2026.

Insurers have agreed to pay about $51.29 for this service. The price depends on where it is billed: about $47.86 from a physician practice, and about $112 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$47.86$33.88 to $60.26
FacilityA hospital or hospital-owned outpatient department$112$42.66 to $155

How much rates vary

Facilitymedian $112 · 10th to 90th $41 to $234Professionalmedian $48 · 10th to 90th $23 to $78
$20$50$100$200facility $112professional $48

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$85.11
Aetna
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$61.66
BCBS North Carolina
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$154.88
Typical High
$158.49
BCBS North Carolina
Setting
Professional
Modifier
None
Typical Low
$22.91
Median
$51.29
Typical High
$81.28
Cigna
Setting
Facility
Modifier
None
Typical Low
$42.66
Median
$112.20
Typical High
$234.42
Cigna
Setting
Professional
Modifier
None
Typical Low
$23.44
Median
$35.48
Typical High
$77.62
Medcost
Setting
Facility
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$60.26
Medcost
Setting
Professional
Modifier
None
Typical Low
$51.29
Median
$51.29
Typical High
$87.10
United
Setting
Professional
Modifier
None
Typical Low
$21.38
Median
$30.90
Typical High
$53.70
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$20.42
Median
$20.42
Typical High
$30.90
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$8.13
Median
$8.13
Typical High
$12.30
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$25.70
Median
$25.70
Typical High
$69.18

Where North Carolina sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 30th of 51

$51.29

AK $115NE $33.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.