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Prader-Willi/Angelman Genetic Test

Minnesota rates for HCPCS 81331

This service is a genetic laboratory test that looks at a specific pattern of gene activity to help diagnose Prader-Willi syndrome or Angelman syndrome, two different inherited conditions that affect development. It is typically ordered when a child shows developmental delay, low muscle tone, feeding difficulties, or other features suggestive of one of these conditions. The test is run on a blood sample.

Rates data updated October 2026.

How much does Prader-Willi/Angelman Genetic Test cost?

$51.29

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $51.29 for this service. The price depends on where it is billed: about $51.29 from a physician practice, and about $51.29 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$51.29$43.65 to $61.66
FacilityA hospital or hospital-owned outpatient department$51.29$47.86 to $162

How much rates vary

Facilitymedian $51 · 10th to 90th $48 to $324Professionalmedian $51 · 10th to 90th $31 to $102
$20$50$100$200$500facility $51professional $51

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$47.86
Median
$47.86
Typical High
$47.86
Aetna
Setting
Professional
Modifier
None
Typical Low
$47.86
Median
$47.86
Typical High
$58.88
BCBS Minnesota
Setting
Facility
Modifier
None
Typical Low
$48.98
Median
$51.29
Typical High
$446.68
BCBS Minnesota
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$45.71
Typical High
$51.29
Cigna
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$162.18
Typical High
$478.63
Cigna
Setting
Professional
Modifier
None
Typical Low
$58.88
Median
$67.61
Typical High
$100.00
Health Partners
Setting
Facility
Modifier
None
Typical Low
$95.50
Median
$158.49
Typical High
$371.54
Health Partners
Setting
Professional
Modifier
None
Typical Low
$58.88
Median
$58.88
Typical High
$97.72
Medica
Setting
Facility
Modifier
None
Typical Low
$61.66
Median
$81.28
Typical High
$102.33
Medica
Setting
Professional
Modifier
None
Typical Low
$26.30
Median
$57.54
Typical High
$263.03
United
Setting
Facility
Modifier
None
Typical Low
$51.29
Median
$51.29
Typical High
$61.66
United
Setting
Professional
Modifier
None
Typical Low
$21.38
Median
$40.74
Typical High
$120.23
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$23.99
Median
$23.99
Typical High
$23.99
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$9.55
Median
$9.55
Typical High
$9.55
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$23.99
Median
$23.99
Typical High
$29.51
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$9.55
Median
$9.55
Typical High
$11.75

Where Minnesota sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 24th of 51

$51.29

AK $115NE $33.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.