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Prader-Willi/Angelman Genetic Test

Maryland rates for HCPCS 81331

This service is a genetic laboratory test that looks at a specific pattern of gene activity to help diagnose Prader-Willi syndrome or Angelman syndrome, two different inherited conditions that affect development. It is typically ordered when a child shows developmental delay, low muscle tone, feeding difficulties, or other features suggestive of one of these conditions. The test is run on a blood sample.

Rates data updated October 2026.

How much does Prader-Willi/Angelman Genetic Test cost?

$38.02

Typical negotiated rate. In Maryland, October 2026.

Insurers have agreed to pay about $38.02 for this service. Most negotiated rates run $34.67 to $40.74.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $38 · 10th to 90th $23 to $51
$20$50$100professional $38

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$38.02
Median
$38.02
Typical High
$46.77
CareFirst
Setting
Professional
Modifier
None
Typical Low
$37.15
Median
$40.74
Typical High
$41.69
Cigna
Setting
Professional
Modifier
None
Typical Low
$26.92
Median
$47.86
Typical High
$147.91
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$51.29
Median
$61.66
Typical High
$75.86
United
Setting
Professional
Modifier
None
Typical Low
$21.38
Median
$25.70
Typical High
$44.67
Wellpoint
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$40.74
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$19.05
Median
$19.05
Typical High
$23.44
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$7.59
Median
$7.59
Typical High
$9.33

Where Maryland sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 48th of 51

$38.02

AK $115NE $33.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.