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Prader-Willi/Angelman Genetic Test

Massachusetts rates for HCPCS 81331

This service is a genetic laboratory test that looks at a specific pattern of gene activity to help diagnose Prader-Willi syndrome or Angelman syndrome, two different inherited conditions that affect development. It is typically ordered when a child shows developmental delay, low muscle tone, feeding difficulties, or other features suggestive of one of these conditions. The test is run on a blood sample.

Rates data updated October 2026.

How much does Prader-Willi/Angelman Genetic Test cost?

$63.10

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $63.10 for this service. The price depends on where it is billed: about $53.70 from a physician practice, and about $91.20 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$53.70$30.90 to $135
FacilityA hospital or hospital-owned outpatient department$91.20$72.44 to $148

How much rates vary

Facilitymedian $91 · 10th to 90th $54 to $204Professionalmedian $54 · 10th to 90th $31 to $263
$20$100$500$2Kfacility $91professional $54

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$41.69
Median
$58.88
Typical High
$58.88
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$56.23
Median
$158.49
Typical High
$229.09
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$30.90
Median
$97.72
Typical High
$263.03
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$81.28
Median
$114.82
Typical High
$162.18
BCBS Massachusetts
Setting
Professional
Modifier
None
Typical Low
$26.30
Median
$26.30
Typical High
$26.30
Cigna
Setting
Facility
Modifier
None
Typical Low
$33.11
Median
$70.79
Typical High
$107.15
Cigna
Setting
Professional
Modifier
None
Typical Low
$30.90
Median
$53.70
Typical High
$199.53
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$72.44
Median
$87.10
Typical High
$5,888.44
Fallon Health
Setting
Professional
Modifier
None
Typical Low
$72.44
Median
$72.44
Typical High
$87.10
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$30.90
Median
$51.29
Typical High
$114.82
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$56.23
Median
$158.49
Typical High
$229.09
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$30.90
Median
$97.72
Typical High
$263.03
United
Setting
Facility
Modifier
None
Typical Low
$45.71
Median
$51.29
Typical High
$61.66
United
Setting
Professional
Modifier
None
Typical Low
$20.42
Median
$30.90
Typical High
$97.72
Well Sense
Setting
Facility
Modifier
None
Typical Low
$44.67
Median
$61.66
Typical High
$93.33
Well Sense
Setting
Professional
Modifier
None
Typical Low
$2,511.89
Median
$2,511.89
Typical High
$3,019.95
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$29.51
Median
$58.88
Typical High
$131.83
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$29.51
Median
$29.51
Typical High
$29.51
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$11.75
Median
$11.75
Typical High
$11.75
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$51.29
Median
$66.07
Typical High
$79.43

Where Massachusetts sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 10th of 51

$63.10

AK $115NE $33.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.