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Prader-Willi/Angelman Genetic Test

Colorado rates for HCPCS 81331

This service is a genetic laboratory test that looks at a specific pattern of gene activity to help diagnose Prader-Willi syndrome or Angelman syndrome, two different inherited conditions that affect development. It is typically ordered when a child shows developmental delay, low muscle tone, feeding difficulties, or other features suggestive of one of these conditions. The test is run on a blood sample.

Rates data updated October 2026.

How much does Prader-Willi/Angelman Genetic Test cost?

$67.61

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $67.61 for this service. The price depends on where it is billed: about $30.90 from a physician practice, and about $148 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$30.90$21.38 to $66.07
FacilityA hospital or hospital-owned outpatient department$148$95.50 to $178

How much rates vary

Facilitymedian $148 · 10th to 90th $39 to $234Professionalmedian $31 · 10th to 90th $21 to $105
$20$50$100$200facility $148professional $31

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$51.29
Median
$107.15
Typical High
$234.42
Aetna
Setting
Professional
Modifier
None
Typical Low
$38.90
Median
$38.90
Typical High
$75.86
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$53.70
Median
$154.88
Typical High
$234.42
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$21.38
Median
$21.38
Typical High
$112.20
Cigna
Setting
Facility
Modifier
None
Typical Low
$30.20
Median
$61.66
Typical High
$162.18
Cigna
Setting
Professional
Modifier
None
Typical Low
$23.99
Median
$30.90
Typical High
$74.13
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$38.90
Median
$45.71
Typical High
$64.57
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$51.29
Median
$72.44
Typical High
$131.83
Select Health
Setting
Facility
Modifier
None
Typical Low
$51.29
Median
$95.50
Typical High
$107.15
Select Health
Setting
Professional
Modifier
None
Typical Low
$35.48
Median
$51.29
Typical High
$75.86
United
Setting
Facility
Modifier
None
Typical Low
$61.66
Median
$61.66
Typical High
$61.66
United
Setting
Professional
Modifier
None
Typical Low
$21.38
Median
$21.38
Typical High
$38.02
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$19.05
Median
$19.50
Typical High
$29.51
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$7.59
Median
$7.76
Typical High
$11.75

Where Colorado sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 6th of 51

$67.61

AK $115NE $33.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.