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SMPD1 Gene Test For Niemann-Pick Disease

South Dakota rates for HCPCS 81330

A laboratory test on a blood sample that checks the SMPD1 gene for a set of well-recognized changes. When both copies of this gene are altered, a fatty substance builds up inside the body's cells, causing Niemann-Pick disease.

Rates data updated July 2026.

How much does SMPD1 Gene Test For Niemann-Pick Disease cost?

$53.70

Typical negotiated rate. In South Dakota, July 2026.

Insurers have agreed to pay about $53.70 for this service. The price depends on where it is billed: about $46.77 from a physician practice, and about $91.20 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$46.77$36.31 to $91.20
FacilityA hospital or hospital-owned outpatient department$91.20$91.20 to $91.20

How much rates vary

Facilitymedian $91 · 10th to 90th $54 to $91Professionalmedian $47 · 10th to 90th $32 to $112
$20$50$100$200facility $91professional $47

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$33.11
Median
$53.70
Typical High
$53.70
Aetna
Setting
Professional
Modifier
Global
Typical Low
$31.62
Median
$38.90
Typical High
$91.20
Cigna
Setting
Facility
Modifier
Global
Typical Low
$91.20
Median
$91.20
Typical High
$91.20
Cigna
Setting
Professional
Modifier
Global
Typical Low
$67.61
Median
$91.20
Typical High
$112.20
Medica
Setting
Facility
Modifier
Global
Typical Low
$44.67
Median
$53.70
Typical High
$331.13
Medica
Setting
Professional
Modifier
Global
Typical Low
$23.99
Median
$23.99
Typical High
$234.42
Sanford Health Plan
Setting
Professional
Modifier
Global
Typical Low
$67.61
Median
$109.65
Typical High
$128.82
United
Setting
Professional
Modifier
Global
Typical Low
$19.95
Median
$28.18
Typical High
$61.66
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$46.77
Median
$46.77
Typical High
$46.77

Where South Dakota sits

The same service costs 3.0 times more in Alaska than in New Mexico. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 19th of 51

$53.70

AK $105NM $35.48

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.