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Cancer-Related Gene Mutation Test, Blood Or Tissue

Illinois rates for HCPCS 81305

This service is a genetic laboratory test that looks for specific mutations in a gene commonly altered in certain blood or bone marrow cancers. Results can help confirm a diagnosis and guide treatment decisions. The test is typically run on a blood or bone marrow sample.

Rates data updated October 2026.

How much does Cancer-Related Gene Mutation Test, Blood Or Tissue cost?

$135

Typical negotiated rate. In Illinois, October 2026.

Insurers have agreed to pay about $135 for this service. The price depends on where it is billed: about $120 from a physician practice, and about $355 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$120$4.47 to $141
FacilityA hospital or hospital-owned outpatient department$355$234 to $603

How much rates vary

Facilitymedian $355 · 10th to 90th $195 to $1,072Professionalmedian $120 · 10th to 90th $3 to $229
$5$20$100$500$2Kfacility $355professional $120

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$144.54
Median
$281.84
Typical High
$524.81
Aetna
Setting
Professional
Modifier
None
Typical Low
$114.82
Median
$144.54
Typical High
$158.49
BCBS Illinois
Setting
Facility
Modifier
None
Typical Low
$208.93
Median
$257.04
Typical High
$2,290.87
BCBS Illinois
Setting
Professional
Modifier
None
Typical Low
$3.47
Median
$120.23
Typical High
$134.90
Cigna
Setting
Facility
Modifier
None
Typical Low
$194.98
Median
$426.58
Typical High
$758.58
Cigna
Setting
Professional
Modifier
None
Typical Low
$79.43
Median
$208.93
Typical High
$288.40
Hally Health
Setting
Professional
Modifier
None
Typical Low
$186.21
Median
$263.03
Typical High
$426.58
Hally Health
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
None
Typical Low
$229.09
Median
$229.09
Typical High
$229.09
United
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$208.93
Typical High
$218.78
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$104.71
Typical High
$177.83
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$72.44
Median
$138.04
Typical High
$263.03
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$28.84
Median
$54.95
Typical High
$107.15
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$72.44
Median
$72.44
Typical High
$79.43
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$28.84
Median
$28.84
Typical High
$31.62

Where Illinois sits

The same service costs 3.8 times more in Alaska than in Delaware. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Illinois· 44th of 51

$135

AK $398DE $105

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.